PMID: 11604591Oct 18, 2001Paper

Pathogenic mechanisms mediating antiphospholipid syndrome

Current Opinion in Rheumatology
P L Meroni, P Riboldi

Abstract

Antiphospholipid antibodies are the marker for antiphospholipid syndrome. There is evidence that these autoantibodies lead to both thrombotic diathesis and obstetrical manifestations. Besides the known interaction with soluble coagulation factors, in vitro and in vivo experimental models and studies in humans recently have shown the ability of antiphospholipid antibodies to modulate functions of cells involved in coagulation homeostasis. These findings support a new hypothesis to explain the paradox of the prolongation of coagulation assays in vitro and the association with thrombophilic diathesis in vivo. Obstetrical manifestations have been linked to a direct antibody effect on the trophoblast leading to defective placentation that is not necessarily associated with thrombotic phenomena. Phospholipid binding proteins such as beta 2 -glycoprotein I appear to behave as a bridge between circulating antiphospholipid antibodies and cellular targets.

References

Nov 5, 1997·American Journal of Reproductive Immunology : AJRI·N Del PapaP L Meroni
Mar 20, 1998·American Journal of Reproductive Immunology : AJRI·N S RoteA K Ng
Feb 17, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·B Galve-de RochemonteixP de Moerloose
Jun 9, 2000·Clinical and Experimental Immunology·J G Hanly, S A Smith
Jun 24, 2000·Journal of Reproduction and Fertility·H S KooistraA Rijnberk
Aug 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S VisvanathanH P McNeil
Aug 29, 2000·Current Opinion in Hematology·Y Sherer, Y Shoenfeld
Sep 2, 2000·Journal of Autoimmunity·D Alarcón-SegoviaA R Villa
Sep 2, 2000·Journal of Autoimmunity·R A Roubey
Sep 2, 2000·Journal of Autoimmunity·S S PierangeliE N Harris

❮ Previous
Next ❯

Citations

Jan 5, 2008·Clinical Reviews in Allergy & Immunology·Pier Luigi MeroniMaria O Borghi
Sep 23, 2003·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·E RaschiP L Meroni
Jul 10, 2003·Autoimmunity Reviews·Pier Luigi MeroniCinzia Testoni
Sep 16, 2003·Journal of Pediatric Hematology/oncology·Tadej AvcinBlaz Rozman
Oct 14, 2004·Annals of the Rheumatic Diseases·S CucnikB Bozic
Dec 14, 2005·Annals of the Rheumatic Diseases·Y ShoenfeldP-L Meroni
Mar 20, 2014·Nature Reviews. Nephrology·Savino SciasciaDario Roccatello
Nov 1, 2006·Women's Health·Sonia ZattiAngela Tincani
Feb 5, 2014·Obstetrics and Gynecology Clinics of North America·William H Kutteh, Candace D Hinote
Mar 13, 2012·Seminars in Arthritis and Rheumatism·Michael SamarkosVioleta Kapsimali
Dec 3, 2014·The American Journal of Pathology·Yuan-Yuan WuElaine Y Lin
Aug 30, 2005·Annals of the New York Academy of Sciences·Silvia S PierangeliGuillermina Girardi
Aug 31, 2004·Journal of Thrombosis and Haemostasis : JTH·D E FerraraS S Pierangeli
Jul 17, 2007·American Journal of Reproductive Immunology : AJRI·Silvia D'IppolitoAlessandro Caruso
Sep 26, 2007·Annals of the New York Academy of Sciences·Nicoletta Di SimoneCaruso Alessandro
Oct 27, 2004·Experimental Gerontology·P L MeroniC Franceschi
Jul 9, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·P L MeroniM O Borghi
Nov 18, 2015·Seminars in Nephrology·Savino SciasciaDario Roccatello
Jan 27, 2015·Current Rheumatology Reports·Giulia PazzolaDoruk Erkan
Nov 11, 2016·Journal of Pharmaceutical and Biomedical Analysis·Angelica PalisiAnna Maria D'Ursi
Jan 13, 2004·Lupus·P L MeroniA Salmaggi
Oct 13, 2005·Lupus·P RiboldiP L Meroni
Oct 16, 2004·Lupus·P L MeroniA Caruso
May 10, 2005·Arthritis and Rheumatism·Mariano Vega-OstertagSilvia S Pierangeli
Aug 21, 2018·Case Reports in Medicine·Myat Han SoeAlueshima Akough-Weir
Sep 11, 2008·American Journal of Reproductive Immunology : AJRI·Jaume Alijotas-ReigLluis Cabero-Roura

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.