Pathogenic Role of a Proliferation-Inducing Ligand (APRIL) in Murine IgA Nephropathy

PloS One
Yang Gyun KimYusuke Suzuki

Abstract

A proliferation-inducing ligand (APRIL) is a member of the tumor necrosis factor (TNF) superfamily. Despite advances in clinical and genetic studies, the details of the pathological roles of APRIL in IgA nephropathy (IgAN) remain to be fully defined. The present study aimed to further assess the pathological role of APRIL using a mouse model of IgAN. Mice with IgAN designated "grouped ddY" (gddY) were intraperitoneally administered an anti-APRIL monoclonal antibody (anti-APRIL Ab) or control IgG (Control Ab) twice each week for 2 weeks starting during the early stage of IgAN (6-7 weeks of age). Urinary albumin, serum IgA, and glomerular IgA deposition were evaluated. We further assessed the inflammatory responses during treatment by measuring the levels of the chemokine fractalkine (FKN) and its receptor CX3CR1 as well as the level of peripheral blood monocytosis. Anti-APRIL Ab treatment significantly decreased albuminuria and tissue damage combined with decreases in serum IgA levels and deposition of glomerular IgA. In contrast, the abundance of IgA+/B220+ or CD138+/B220+ B cells in the spleen and bone marrow, respectively, was unchanged. Treating gddY mice with anti-April Ab reduced the overexpression of FKN/CX3CR1 in the kid...Continue Reading

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Citations

Dec 26, 2017·Frontiers in Immunology·Yale LiuYumin Xia
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Jul 8, 2021·Seminars in Immunopathology·Renato C Monteiro, Yusuke Suzuki
Sep 11, 2021·Alimentary Pharmacology & Therapeutics·Albert J Czaja

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Methods Mentioned

BETA
ELISA
light microscopy
PCR
flow cytometry

Software Mentioned

GraphPad
GraphPad Prism
SPSS

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