Pathogenic role of antimyeloperoxidase antibodies

La Revue de médecine interne
Philippe GuilpainL Guillevin

Abstract

Antimyeloperoxidase antibodies are a variety of antineutrophil cytoplasm antibodies (Anca), which can be detected in systemic small-sized vessel vasculitides such as microscopic polyangiitis, Wegener's granulomatosis and Churg-Strauss syndrome. Antimyeloperoxidase antibodies have been also associated with the development of lung fibrosis. Their pathogenic role has been well established, both in vitro and in vivo. These autoantibodies can activate neutrophils and trigger their oxidative burst leading to the release of free oxygen species and cytotoxic proteins. The oxidative burst is deleterious for the endothelium. Another mechanism by which antimyeloperoxidase may act is the activation of myeloperoxydase leading to an increased production of hypochlorous acid, which is highly toxic for the endothelial cells. These mechanisms contribute to the development of vasculitis.

References

Aug 1, 1991·British Journal of Haematology·J A SavigeJ C Duggan
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R J FalkJ C Jennette
May 1, 1987·The Journal of Clinical Investigation·R J JohnsonS J Klebanoff
Dec 14, 1995·Biochemical and Biophysical Research Communications·R G WoolfsonP W Mathieson
Feb 1, 1994·Arthritis and Rheumatism·J C JennetteC G Kallenberg
Apr 1, 1993·The Journal of Experimental Medicine·E BrouwerC G Kallenberg
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·K KinjohR A Good
Aug 1, 1996·Clinical Immunology and Immunopathology·S von SchmiedebergE Gleichmann
Feb 14, 1998·Kidney International·P HeeringaC G Kallenberg
Sep 3, 1999·American Journal of Respiratory and Critical Care Medicine·P FoucherC G Kallenberg
Jun 24, 2005·The American Journal of Pathology·Hong XiaoJ Charles Jennette
Apr 25, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Renato Alberto SinicoCarlo Buzio
Oct 31, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ai-Hua ZhangHai-Yan Wang
Jun 30, 2007·Arthritis and Rheumatism·Philippe GuilpainFrédéric Batteux
Oct 30, 2008·Annals of the Rheumatic Diseases·B HervierUNKNOWN French Vasculitis Study Group

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Citations

Sep 12, 2012·La Revue de médecine interne·J TracletV Cottin
Jan 14, 2012·La Revue de médecine interne·F PasquetL Guilloton
May 20, 2015·Gastroenterology Research and Practice·Jan HeidemannTobias Meister

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