Pathogenicity and antigenicity of a new variant of Korean nephropathogenic infectious bronchitis virus.

Journal of Veterinary Science
Kang Seuk ChoiJun Hun Kwon

Abstract

Despite the existence of an active vaccination program, recently emerged strains of nephropathogenic infectious bronchitis virus (IBV) in Korea have caused significant economic losses in the poultry industry. In this study, we assessed the pathogenic and antigenic characteristics of a K-IIb type field strain of IBV that emerged in Korea since 2003, such as Kr/Q43/06. Specific pathogen free 1-week-old chickens exhibited severe respiratory symptoms (dyspnea) and nephropathogenic lesions (swollen kidneys with nephritis and urate deposits) following challenge with the recent IBV field strain. The antigenic relatedness (R value), based on a calculated virus neutralization index, of the K-IIb type field strain and K-IIa type strain KM91 (isolated in 1991) was 30%, which indicated that the recent strain, Kr/Q43/06, is a new variant that is antigenically distinct from strain KM91. This report is the first to document the emergence of a new antigenic variant of nephropathogenic IBV in chicken from Korea.

References

Jun 30, 2004·Avian Pathology : Journal of the W.V.P.A·Shengwang Liu, Xiangang Kong
Sep 23, 2006·Avian Pathology : Journal of the W.V.P.A·Yury A BochkovVladimir V Drygin
Jan 22, 2008·The Veterinary Record·R E GoughR C Jones

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Citations

Nov 23, 2012·Emerging Infectious Diseases·Jinling FengGuozhong Zhang
Jan 1, 2012·ISRN Veterinary Science·Mustafa AbabnehMohammad Al-Zghoul
Jan 25, 2017·Archives of Virology·Seung-Min HongJae-Hong Kim

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