Pathogenicity and cross-reactive immune responses of a historical and a contemporary Senecavirus A strains in pigs

Virology
Maureen H V FernandesDiego G Diel

Abstract

The goals of this study were to compare the pathogenicity and infection dynamics of a historical and a contemporary SVA strains (SVV 001 and SD15-26) and to assess cross-neutralizing and cross-reactive T cell responses following experimental infection in pigs. Both SVA strains successfully infected all inoculated animals, resulting in viremia and robust antibody and cellular immune responses. SVA SD15-26 infection resulted in characteristic clinical signs and vesicular lesions, however, SVA SVV 001 did not cause overt clinical disease with inoculated animals remaining clinically normal during the experiment. Notably, neutralization- and -recall IFN-γ expression-assays revealed marked cross-neutralizing antibody and cross-reactive T cell responses between the two viral strains. Together these results demonstrate that the historical SVA SVV 001 strain presents low virulence in pigs when compared to the contemporary SVA SD15-26 strain. Additionally, immunological assays indicate that SVA SVV 001 and SD15-26 are antigenically related and share conserved antigenic determinants.

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Citations

Dec 21, 2019·The Journal of General Virology·Lok R JoshiDiego G Diel
Aug 23, 2019·Journal of Virology·Mayara F MaggioliDiego G Diel
Dec 19, 2019·Frontiers in Immunology·Bishwas SharmaDiego G Diel
Mar 29, 2019·Frontiers in Immunology·Maureen H V FernandesDiego G Diel
Dec 21, 2020·Veterinary Microbiology·Alexandra C BuckleyKelly M Lager
Jun 16, 2021·Microbial Pathogenesis·Thalita Evani Silva de OliveiraSelwyn Arlington Headley
Aug 24, 2021·The Journal of General Virology·Maureen H V FernandesDiego G Diel
Sep 3, 2021·Transboundary and Emerging Diseases·Leonardo C CasertaDiego G Diel

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