Pathogenicity and Viral Shedding of MERS-CoV in Immunocompromised Rhesus Macaques

Frontiers in Immunology
Joseph PrescottVincent J Munster

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) has recently emerged in the Middle East. Since 2012, there have been approximately 2,100 confirmed cases, with a 35% case fatality rate. Disease severity has been linked to patient health status, as people with chronic diseases or an immunocompromised status fare worse, although the mechanisms of disease have yet to be elucidated. We used the rhesus macaque model of mild MERS to investigate whether the immune response plays a role in the pathogenicity in relation to MERS-CoV shedding. Immunosuppressed macaques were inoculated with MERS-CoV and sampled daily for 6 days to assess their immune statues and to measure viral shedding and replication. Immunosuppressed macaques supported significantly higher levels of MERS-CoV replication in respiratory tissues and shed more virus, and virus disseminated to tissues outside of the respiratory tract, whereas viral RNA was confined to respiratory tissues in non-immunosuppressed animals. Despite increased viral replication, pathology in the lungs was significantly lower in immunosuppressed animals. The observation that the virus was less pathogenic in these animals suggests that disease has an immunopathogenic component and shows that...Continue Reading

References

Dec 31, 2003·Trends in Immunology·Paresh DandonaArindam Bandyopadhyay
Jun 15, 2010·Current Opinion in HIV and AIDS·Peter W Hunt
Oct 14, 2010·Seminars in Respiratory and Critical Care Medicine·Keith C Meyer
Oct 19, 2012·The New England Journal of Medicine·Ali M ZakiRon A M Fouchier
Dec 13, 2012·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·V M CormanC Drosten
Mar 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jason DeFuriaBarbara S Nikolajczyk
Apr 5, 2013·The New England Journal of Medicine·Vincent J MunsterHeinz Feldmann
Jun 21, 2013·The New England Journal of Medicine·Abdullah AssiriUNKNOWN KSA MERS-CoV Investigation Team
Jun 21, 2013·The Lancet Infectious Diseases·Christian DrostenClemens-Martin Wendtner
Sep 26, 2013·Proceedings of the National Academy of Sciences of the United States of America·Emmie de WitVincent J Munster
Oct 22, 2013·Immunity·Steven G DeeksDaniel C Douek
Mar 15, 2014·Current Opinion in Pulmonary Medicine·David S HuiAlimuddin Zumla
Apr 26, 2014·The Pediatric Infectious Disease Journal·Ziad A MemishAbdullah A Al-Rabeeah
Aug 22, 2014·PLoS Pathogens·Darryl FalzaranoVincent J Munster
Oct 12, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Mustafa SaadAli M Albarrak
Nov 15, 2014·Infection and Drug Resistance·Jaffar A Al-Tawfiq, Ziad A Memish
May 24, 2015·Paediatric Respiratory Reviews·G R BanikH Rashid
Jun 28, 2016·Nature Reviews. Microbiology·Emmie de WitVincent J Munster
Sep 30, 2016·The New England Journal of Medicine·Myoung-Don OhNam Joong Kim
Dec 13, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Seung Woo KimMoran Ki
May 27, 2017·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Si-Ho KimKyong Ran Peck

❮ Previous
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Citations

Mar 22, 2019·Viruses·W WidagdoBart L Haagmans
Apr 26, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Silvia NatoliAntonio Pisani
May 15, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Rachel BushKiran Upadhyay
Apr 23, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·P GisondiL Naldi
Jul 9, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Quirino LaiJan Lerut
Aug 9, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Georgios ChamilosDimitrios P Kontoyiannis
Feb 15, 2020·Proceedings of the National Academy of Sciences of the United States of America·Emmie de WitHeinz Feldmann
Jul 10, 2020·Nature Reviews. Neurology·Catharina KorsukewitzHeinz Wiendl
Jun 11, 2020·Journal of Crohn's & Colitis·S SebastianL Peyrin-Biroulet
Jun 26, 2020·Epidemiology and Infection·Jing HanShi-Feng Shao
Jan 20, 2019·Viruses·Craig Schindewolf, Vineet D Menachery
Aug 21, 2019·Frontiers in Microbiology·Chean Yeah YongWen Siang Tan
Aug 15, 2020·Frontiers in Immunology·Lea Skak Filtenborg FrederiksenAneesh Thakur
Apr 28, 2020·Laboratory animal research·Mee Sook ParkMan-Seong Park
Apr 30, 2020·Alimentary Pharmacology & Therapeutics·Aysha H Al-AniBritt Christensen
Oct 28, 2020·SN Comprehensive Clinical Medicine·Jose Manuel Gutierrez AmezcuaDavid Zagzag
Sep 14, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Jieqi WenYizhou Jiang
Jan 28, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Georgios ChamilosDimitrios P Kontoyiannis
Jan 8, 2022·Journal of Basic and Clinical Physiology and Pharmacology·Ajay Kumar Shukla, Saurav Misra

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Methods Mentioned

BETA
bronchoalveolar lavage

Software Mentioned

ImageScope

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