Pathogenicity comparison of duck Tembusu virus in different aged Cherry Valley breeding ducks

BMC Veterinary Research
Chuanwei LvSidang Liu

Abstract

Although several studies have revealed that the sensitivity of ducklings to duck Tembusu virus (DTMUV) was related to age, however, DTMUV was originally isolated from egg-laying ducks, and the ovary was the target organ of this virus. Cherry Valley breeding ducks aged 15- and 55-week-old (they are reserve breeding ducks and the normal egg-laying breeding ducks, respectively) were infected with DTMUV, using intramuscular injection, to study the effect of age-related difference on the pathogenicity of DTMUV in breeding ducks. Examinations of clinical symptoms, gross and microscopic lesions, viral loads, cytokines and serum neutralizing antibodies were performed. Results showed that obvious clinical symptoms, such as depression, ruffled feathers, ataxia and egg-laying drop were observed in the 55-week-old laying ducks, with five ducks dying at 5-7 days post infection (dpi). The 15-week-old ducks showed slight symptoms during infection. Gross lesions were severe and characterized by the congestion, hemorrhage and swelling of some organs in the 55-week-old ducks, including the hemorrhage of endocardium, hepatomegaly, splenomegaly, oviduct hemorrhage, hyperemia and deformation of the ovary. Mild endocardial hemorrhage and hepatosplen...Continue Reading

References

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Citations

May 1, 2020·Frontiers in Cellular and Infection Microbiology·Zhiqiang HuRenyong Jia
Aug 29, 2020·Viruses·Bradley J BlitvichBrian D Foy
Jul 10, 2020·Veterinary Research·Ning LiSidang Liu
Mar 16, 2021·The Journal of Veterinary Medical Science·Sittinee KulprasertsriTakashi Kimura
Aug 29, 2021·Pathogens·Rodolphe HamelDorothée Missé

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Datasets Mentioned

BETA
KY623434.1

Methods Mentioned

BETA
PCR
light microscopy
ELISA

Software Mentioned

Graph Prism
GraphPad

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