Pathogenicity of an attenuated, temperature-sensitive mutant of western equine encephalitis virus induced by a chemical mutagen.

Infection and Immunity
N Takayama, M Nakano

Abstract

To know the pathogenicity of the chemically induced, temperature-sensitive (ts) mutant of western equine encephalitis virus, designated tsNG39, the lethality for mice injected with tsNG39, virus yield, interferon production, and histological changes in the brains of these mice were examined in parallel with those of mice inoculated with the parent strain (PS). All of the mice injected intracranially with PS died within 3.5 days after injection irrespective of the inoculum size of virus, whereas the lethality of the mice inoculated with tsNG39 varied from 94.3 to 65.5% among groups of mice and this variation seemed to be correlated with the inoculum size of virus rather than with the maximum virus titer in the brain. By histological examination, two types of changes in the brain were distinguished, inflammatory and degenerative ones. Inflammatory changes were more prominent in the brains injected with tsNG39 than in those receiving PS. Degenerative changes were dominant in the brains injected with PS, but they were slight in the earlier phase of infection by tsNG39 became prominent only later. The degree of degenerative change was well correlated with both the virus titer in the mouse brain and the death pattern of mice injected...Continue Reading

References

Jan 4, 1968·The New England Journal of Medicine·R T Johnson, C A Mims
May 1, 1973·Japanese Journal of Microbiology·N Takayama, B Simizu
Jan 1, 1972·Archiv für die gesamte Virusforschung·B Simizu, N Takayama
Feb 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·G A Cole, C L Wisseman
Jan 1, 1940·The Journal of Experimental Medicine·L S King

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