Pathogenicity of an FAdV-4 isolate to chickens and its genomic analysis

Journal of Zhejiang University. Science. B
Kai-Kun MoJi-Yong Zhou

Abstract

Fowl adenovirus serotype 4 (FAdV-4) strain SD1511 was isolated from chickens with severe inclusion body hepatitis and hydropericardium syndrome in Shandong Province, China. The isolate was cultured in primary chicken embryo kidney cells. A study of pathogenicity indicated that SD1511 readily infected 7-35-d-old chickens by intramuscular injection and intranasal and oral routes, causing 50%-100% mortality. The 35-d-old chickens suffered more severe infection than 7- and 21-d-old chickens with mortality highest in the intramuscular injection group. The serum from surviving chickens showed potent viral neutralizing capability. The complete genome of SD1511 was sequenced and analyzed. The strain was found to belong to the FAdV-4 cluster with more than 99% identity with the virulent FAdV-4 strains isolated in China in recent years except for some distinct variations, including deletions of open reading frame 27 (ORF27), ORF48, and part of ORF19. Our findings suggest that SD1511 might be used as a prototype strain for the study of pathogenesis and vaccine development.

References

Jun 20, 1995·Proceedings of the National Academy of Sciences of the United States of America·S LundO Pedersen
Oct 8, 1998·Journal of Virological Methods·H S AlexanderE Nagy
Jul 6, 2000·Research in Veterinary Science·K Ganesh, R Raghavan
Jan 19, 2008·Avian Pathology : Journal of the W.V.P.A·Davor OjkicSusantha Gomis
Jun 1, 2000·Avian Pathology : Journal of the W.V.P.A·M Hess
Apr 21, 2012·The Journal of Veterinary Medical Science·Masaji MaseFujiko Minami
Oct 22, 2013·Veterinary Microbiology·Győző L KajánMária Benkő
May 26, 2016·Emerging Microbes & Infections·Jianqiang YeAijian Qin
Oct 23, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Huixin LiShengwang Liu
Sep 28, 2017·Avian Pathology : Journal of the W.V.P.A·Anna SchachnerMichael Hess

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Citations

Sep 12, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Lili WangMinghua Yan

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