Pathogenicity of Candida tropicalis and Candida albicans after gastrointestinal inoculation in mice.

Infection and Immunity
J R WingardW H Burns

Abstract

The ability of clinical isolates of Candida albicans and candida tropicalis to invade through normal and damaged gastrointestinal mucosa was determined. Adult mice were treated with either gentamicin or gentamicin and cytarabine. Suspensions of yeast cells (10(7)) were administered through a catheter intraesophageally. Invasion was determined by culturing liver, kidney, and lung tissue from mice sacrificed after 48 h. C. albicans and C. tropicalis were incapable of invading through normal gastrointestinal mucosa in mice treated only with gentamicin. Two isolates of C. tropicalis penetrated the damaged gastrointestinal mucosa in 69% (49 of 71) of mice treated with gentamicin and cytarabine. In contrast, three isolates of C. albicans penetrated he damaged gastrointestinal mucosa in only 23% (14 of 62) of mice. These results suggest that C. tropicalis is more capable of invading through damaged gastrointestinal mucosa than C. albicans. The observations in this mouse model parallel those seen in patients on cytotoxic drugs. Therefore, this model offers a tool for investigation of the pathogenicity of these organisms in a model analogous to the compromised host.

References

Oct 1, 1979·Annals of Internal Medicine·J R WingardR Saral
Oct 1, 1978·The Tohoku Journal of Experimental Medicine·T Umenai
Jun 1, 1976·Infection and Immunity·A DeMariaF von Lichtenberg
Jul 10, 1975·The New England Journal of Medicine·W D Bloomer, S Hellman
Jun 1, 1975·Cancer Treatment Reviews·G P Bodey
May 1, 1974·Annals of Surgery·H H StoneJ Z Cuzzell
Apr 1, 1973·The Journal of Surgical Research·H H StoneW R Kitchens
Jul 1, 1973·The Journal of Surgical Research·R P HummelB G Macmillan
May 1, 1974·Annals of Internal Medicine·R C YoungA S Levine
Jul 1, 1962·The Journal of Pathology and Bacteriology·R HURLEY, H I WINNER

❮ Previous
Next ❯

Citations

Jul 20, 2004·Clinical Microbiology Reviews·David Kaufman, Karen D Fairchild
Aug 1, 1990·Applied and Environmental Microbiology·M A GleesonJ M Cregg
Jul 28, 2006·Antimicrobial Agents and Chemotherapy·Karl V ClemonsDavid A Stevens
Aug 1, 1987·Journal of Clinical Microbiology·R A FromtlingD M Giltinan
Sep 1, 1985·Journal of Clinical Microbiology·I F SalkinM E Kemna
Sep 1, 1996·Antimicrobial Agents and Chemotherapy·G SamonisG P Bodey
May 1, 1988·The Journal of Surgical Research·S InoueR R Cardell
Jun 1, 1991·The Journal of Surgical Research·H P RedmondJ M Daly
May 1, 1992·European Journal of Epidemiology·T J Walsh, P A Pizzo
Apr 1, 1993·Mycopathologia·R A Greenfield, W A Joyce
Jan 7, 2003·Infectious Disease Clinics of North America·Jose A Vazquez, Jack D Sobel
Jan 7, 2003·Infectious Disease Clinics of North America·Brahm H SegalFrancisco Menichetti
Dec 1, 1987·European Journal of Clinical Microbiology·M PfallerR Gingrich
Jan 1, 1989·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·G T ColeL M Pope
May 1, 1988·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·S P ReddingJ L Hicks
Jul 1, 1993·Leukemia & Lymphoma·P M FlynnW T Hughes
Nov 1, 1989·JPEN. Journal of Parenteral and Enteral Nutrition·S InoueP Gura
Jan 1, 1987·Critical Reviews in Microbiology·W L Whelan
Jan 1, 1985·Critical Reviews in Microbiology·D PoulainA Vernes
Apr 24, 2010·Journal of Medical Microbiology·Rajendra J KothavadeM H Panthaki

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.