Pathogenicity of Helicobacter pylori in cancer development and impacts of vaccination

Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Hadi Maleki KakelarYadollah Omidi

Abstract

Helicobacter pylori affect around 50% of the population worldwide. More importantly, the gastric infection induced by this bacterium is deemed to be associated with the progression of distal gastric carcinoma and gastric mucosal lymphoma in the human. H. pylori infection and its prevalent genotype significantly differ across various geographical regions. Based on numerous virulence factors, H. pylori can target different cellular proteins to modulate the variety of inflammatory responses and initiate numerous "hits" on the gastric mucosa. Such reactions lead to serious complications, including gastritis and peptic ulceration, gastric cancer and gastric mucosa-associated lymphoid structure lymphoma. Therefore, H. pylori have been considered as the type I carcinogen by the Global Firm for Research on Cancer. During the two past decades, different reports revealed that H. pylori possess oncogenic potentials in the gastric mucosa through a complicated interplay between the bacterial factors, various facets, and the environmental factors. Accordingly, numerous signaling pathways could be triggered in the development of gastrointestinal diseases (e.g., gastric cancer). Therefore, the main strategy for the treatment of gastric cancer ...Continue Reading

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Citations

Feb 28, 2019·Applied Microbiology and Biotechnology·Mehdi FouladiYadollah Omidi
Mar 3, 2020·Journal of Drug Targeting·Siamak AlizadehYadollah Omidi
Sep 15, 2020·Journal of Gastrointestinal Cancer·Majid Alipour
Jul 25, 2019·World Journal of Gastroenterology : WJG·Stella SmithRinaldo Pellicano
Aug 11, 2020·Journal of Immunology Research·Siru Nie, Yuan Yuan
Aug 31, 2019·Cancer Investigation·Sidhant JainPooja Jain
Oct 31, 2019·Journal of Oncology·Marco Antonio Hernández-LunaRosendo Luria-Pérez
Sep 29, 2019·World Journal of Gastroenterology : WJG·Huan LiXiao-Ming Liu
Mar 2, 2021·World Journal of Gastroenterology : WJG·Vasiliy Ivanovich ReshetnyakIgor Veniaminovich Maev
Jul 5, 2021·European Journal of Medicinal Chemistry·Elham GhobadiSaeed Emami

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