Pathogenicity of human antibodies against myelin oligodendrocyte glycoprotein

Annals of Neurology
Melania SpadaroEdgar Meinl

Abstract

Autoantibodies against myelin oligodendrocyte glycoprotein (MOG) occur in a proportion of patients with inflammatory demyelinating diseases of the central nervous system (CNS). We analyzed their pathogenic activity by affinity-purifying these antibodies (Abs) from patients and transferring them to experimental animals. Patients with Abs to MOG were identified by cell-based assay. We determined the cross-reactivity to rodent MOG and the recognized MOG epitopes. We produced the correctly folded extracellular domain of MOG and affinity-purified MOG-specific Abs from the blood of patients. These purified Abs were used to stain CNS tissue and transferred in 2 models of experimental autoimmune encephalomyelitis. Animals were analyzed histopathologically. We identified 17 patients with MOG Abs from our outpatient clinic and selected 2 with a cross-reactivity to rodent MOG; both had recurrent optic neuritis. Affinity-purified Abs recognized MOG on transfected cells and stained myelin in tissue sections. The Abs from the 2 patients recognized different epitopes on MOG, the CC' and the FG loop. In both patients, these Abs persisted during our observation period of 2 to 3 years. The anti-MOG Abs from both patients were pathogenic upon int...Continue Reading

References

Aug 1, 1992·Annals of Neurology·K VassH Lassmann
Jul 7, 1998·The Journal of Experimental Medicine·T LitzenburgerA Iglesias
Jun 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hans-Christian von BüdingenClaude P Genain
Jul 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Constanze BreithauptUwe Jacob
Dec 5, 2006·Proceedings of the National Academy of Sciences of the United States of America·Dun ZhouBernhard Hemmer
Jan 16, 2008·Archives of Neurology·Sean J PittockBrian G Weinshenker
Jul 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Constanze BreithauptUwe Jacob
May 17, 2012·Therapeutic Advances in Neurological Disorders·Marie Cathrin Mayer, Edgar Meinl
Jun 26, 2013·Nature Reviews. Neurology·Markus ReindlThomas Berger
Aug 2, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Natascha C PereraDieter E Jenne
Sep 10, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marie C MayerEdgar Meinl
Apr 2, 2014·Acta Neuropathologica Communications·Samira SaadounMarios C Papadopoulos
Apr 5, 2014·Annals of Neurology·Maarten J TitulaerJosep Dalmau
Oct 24, 2014·Neurology. Neuroimmunology and Neuroinflammation·Russell C DaleFabienne Brilot
Oct 24, 2014·Neurology. Neuroimmunology and Neuroinflammation·Michel Varrin-DoyerScott S Zamvil
Nov 5, 2014·Neurology. Neuroimmunology and Neuroinflammation·Sudarshini RamanathanFabienne Brilot
Jan 31, 2015·Neurology. Neuroimmunology and Neuroinflammation·Scott S Zamvil, Anthony J Slavin
Mar 31, 2015·Annals of Clinical and Translational Neurology·Melania SpadaroTania Kümpfel
Mar 31, 2015·Neurology. Neuroimmunology and Neuroinflammation·Patrick WatersAngela Vincent
Nov 21, 2015·Neurology. Neuroimmunology and Neuroinflammation·Franziska Di PauliThomas Berger
Dec 20, 2015·Journal of Neuroinflammation·Manfred WuhrerMarkus Krumbholz
Dec 29, 2015·Autoimmunity Reviews·Sudarshini RamanathanFabienne Brilot
Mar 10, 2016·Proceedings of the National Academy of Sciences of the United States of America·Anne-Christine FlachAlexander Flügel
Jun 22, 2016·Proceedings of the National Academy of Sciences of the United States of America·Simone M BrändleKlaus Dornmair
Jul 28, 2016·Neurology. Neuroimmunology and Neuroinflammation·Melania SpadaroTania Kümpfel
Dec 19, 2016·Acta Neuropathologica·Tanja KuhlmannHans Lassmann
Feb 2, 2017·Annual Review of Immunology·Florian Weisel, Mark Shlomchik
Mar 24, 2017·Neurology. Neuroimmunology and Neuroinflammation·Peter KörtvélyessyFrank Leypoldt
Apr 2, 2017·Brain : a Journal of Neurology·Maciej JurynczykJacqueline Palace
May 5, 2017·The Neurologist·Thashi ChangAngela Vincent
May 24, 2017·Frontiers in Immunology·Patrick PeschlMarkus Reindl
Jul 7, 2017·Science Translational Medicine·Fumitaka ShimizuJeffrey L Bennett
Sep 15, 2017·Nature Reviews. Rheumatology·Michaela SeelingFalk Nimmerjahn

❮ Previous
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Citations

Jan 24, 2019·Current Treatment Options in Neurology·Yael Hacohen, Brenda Banwell
May 9, 2019·Physiological Reviews·Christine StadelmannMikael Simons
Mar 14, 2019·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·John J Chen, Clare L Fraser
Nov 13, 2019·Nature Reviews. Neuroscience·Joseph J SabatinoScott S Zamvil
Dec 2, 2019·Journal of Neuroinflammation·Che SergueraKumaran Deiva
Oct 16, 2019·Neurology. Neuroimmunology and Neuroinflammation·Stephan WinklmeierEdgar Meinl
Apr 2, 2020·Expert Opinion on Biological Therapy·Ankelien DuchowJudith Bellmann-Strobl
May 16, 2020·Brain : a Journal of Neurology·Yoshiki TakaiUNKNOWN Japan MOG-antibody Disease Consortium
Sep 5, 2019·Acta Neuropathologica Communications·Fiona TeaUNKNOWN Australasian and New Zealand MOG Study Group
Dec 19, 2018·Nature Reviews. Neurology·Markus Reindl, Patrick Waters
Aug 21, 2019·Frontiers in Pharmacology·Sara GrassiPaola Giussani
Aug 21, 2020·Proceedings of the National Academy of Sciences of the United States of America·Stefanie KuertenLawrence Steinman
Sep 5, 2020·Journal of Neuroinflammation·Sven JariusUNKNOWN in cooperation with the BIOMARKER study group and the Neuromyelitis optica Study Group (NEMOS)
Oct 1, 2019·Journal of Child Neurology·Soren JonzzonJennifer S Graves
Aug 28, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·D D EliseevaM N Zakharova
Jul 31, 2020·Cellular & Molecular Immunology·Alicia ZouFabienne Brilot
Sep 5, 2020·Journal of Neuroinflammation·Sven JariusUNKNOWN in cooperation with the Neuromyelitis Optica Study Group (NEMOS)
Oct 23, 2020·Annals of Neurology·Giancarlo ComiUNKNOWN Expert Panel of the 27th Annual Meeting of the European Charcot Foundation
Nov 18, 2020·Klinische Monatsblätter für Augenheilkunde·Brigitte WildemannSven Jarius
Nov 22, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Jia LiuSatoshi Kuwabara
Dec 2, 2020·Acta Neuropathologica Communications·Ramona GerhardsEdgar Meinl
Jan 4, 2021·Journal of Neurology·Lindsey B De LottFiona Costello
Oct 24, 2020·Nature Reviews. Disease Primers·Sven JariusBrigitte Wildemann
Nov 17, 2020·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Thaís ArmangueUNKNOWN E.U. paediatric MOG consortium
Jul 7, 2020·Multiple Sclerosis and Related Disorders·Daniel H WhittamAnu Jacob
Nov 20, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Wei SunE Sally Ward
Jan 8, 2021·Neurology. Neuroimmunology and Neuroinflammation·Jonas GrafHans-Peter Hartung
Jun 17, 2021·Neurology. Neuroimmunology and Neuroinflammation·Kathrin SchandaMarkus Reindl
Jul 6, 2021·Frontiers in Immunology·C ZografouP Stathopoulos
Jul 6, 2021·European Journal of Ophthalmology·Jean-Baptiste DucloyerPierre Lebranchu

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