Pathogenicity of the Korean H5N8 highly pathogenic avian influenza virus in commercial domestic poultry species

Avian Pathology : Journal of the W.V.P.A
Dong-Hun LeeChang-Seon Song

Abstract

In 2014, the highly pathogenic avian influenza (HPAI) virus H5N8 triggered outbreaks in wild birds and poultry farms in South Korea. In the present study, we investigated the pathogenicity of the H5N8 HPAI virus, belonging to the clade 2.3.4.4, in different species of poultry. For this, we examined clinical signs and viral shedding levels following intranasal inoculation of the virus in 3-week-old commercial layer chickens and quails, 10-week-old Korean native chickens, and 8-week-old Muscovy ducks. Intranasal inoculation with 10(6.0) viruses at 50% egg-infective dose resulted in 100% mortality in the layer chickens (8/8) and quails (4/4), but 60% and 0% deaths in the Korean native chickens (3/5) and Muscovy ducks (0/4), respectively. In addition, transmission of the inoculated virus to contact-exposed birds was evident in all the species used in this study. Based on our results, we conclude that the H5N8 HPAI virus has lower pathogenicity and transmissibility in poultry species compared with previously reported H5N1 HPAI viruses.

References

Dec 6, 2005·The Journal of Veterinary Medical Science·Yong-kuk KwonJae-hong Kim
Nov 28, 2006·Vaccine·Dennis J Alexander
May 15, 2007·Avian Diseases·Mary J Pantin-Jackwood, David E Swayne
Oct 6, 2009·Veterinary Microbiology·Hye-Ryoung KimYi-Seok Joo
Nov 22, 2011·Journal of Wildlife Diseases·Dong-Hun LeeChang-Seon Song
Jan 29, 2014·Avian Pathology : Journal of the W.V.P.A·Kateri BertranNatàlia Majó
May 27, 2014·Emerging Infectious Diseases·Youn-Jeong LeeHee-Soo Lee
Dec 31, 2014·Journal of Veterinary Science·Byung-Min SongYoun-Jeong Lee
Jan 28, 2015·Emerging Infectious Diseases·Hyun-Mi KangYoun-Jeong Lee

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Citations

Mar 9, 2017·International Reviews of Immunology·Anamika MishraAshwin Ashok Raut
Sep 2, 2017·Journal of Veterinary Science·Dong-Hun LeeDavid E Swayne
Jul 28, 2020·Scientific Reports·Peter H F HobbelenThomas J Hagenaars
Jul 22, 2018·Emerging Microbes & Infections·Christian GrundMartin Beer
May 6, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Sarah C HillOliver G Pybus
Dec 22, 2017·EFSA Journal·UNKNOWN European Food Safety AuthorityCornelia Adlhoch
Oct 16, 2017·EFSA Journal·UNKNOWN European Food Safety AuthorityFrank Verdonck
Dec 4, 2020·Comparative Immunology, Microbiology and Infectious Diseases·Mohammed A RohaimMuhammad Munir

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Methods Mentioned

BETA
ELISA

Related Concepts