Pathogenicity patterns of mucormycosis: epidemiology, interaction with immune cells and virulence factors

Medical Mycology
Mohamed I Abdelwahab Hassan, Kerstin Voigt

Abstract

Fungi of the basal lineage order Mucorales are able to cause infections in animals and humans. Mucormycosis is a well-known, life-threatening disease especially in patients with a compromised immune system. The rate of mortality and morbidity caused by mucormycosis has increased rapidly during the last decades, especially in developing countries. The systematic, phylogenetic, and epidemiological distributions of mucoralean fungi are addressed in relation to infection in immunocompromised patients. The review highlights the current achievements in (i) diagnostics and management of mucormycosis, (ii) the study of the interaction of Mucorales with cells of the innate immune system, (iii) the assessment of the virulence of Mucorales in vertebrate and invertebrate infection models, and (iv) the determination of virulence factors that are key players in the infection process, for example, high-affinity iron permease (FTR1), spore coat protein (CotH), alkaline Rhizopus protease enzyme (ARP), ADP-ribosylation factor (ARF), dihydrolipoyl dehydrogenase, calcineurin (CaN), serine and aspartate proteases (SAPs). The present mini-review attempts to increase the awareness of these difficult-to-manage fungal infections and to encourage resear...Continue Reading

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Citations

Jul 23, 2019·Environmental Microbiology·Mohamed I Abdelwahab HassanMarc Thilo Figge
Mar 20, 2020·Genes·Carlos LaxFrancisco Esteban Nicolás
Jul 14, 2020·PLoS Genetics·Carlos Pérez-ArquesFrancisco Esteban Nicolás
May 24, 2019·Pathogens·Wibke KrügerMaria Joanna Niemiec
Jun 26, 2020·Frontiers in Microbiology·Zoltan CseresnyesMarc Thilo Figge
Jul 2, 2020·Journal of Fungi·Francisco E NicolásVictoriano Garre
Aug 21, 2020·FEMS Microbiology Ecology·Mahaldeep Kaur, Rachna Singh
Jul 16, 2020·Expert Review of Hematology·Livio PaganoAlessandro Busca
Sep 13, 2019·Microbial Pathogenesis·J Alberto Patiño-MedinaVictor Meza-Carmen
Jan 28, 2021·Current Tropical Medicine Reports·Berenice Morales-FrancoClaudia Lisette Charles-Niño
Oct 30, 2020·International Medical Case Reports Journal·Hanna JungTak-Hyuk Oh
Feb 19, 2021·Computational and Structural Biotechnology Journal·Mohamed I Abdelwahab HassanKerstin Voigt
Apr 21, 2021·Nucleic Acids Research·José Tomás Cánovas-MárquezVictoriano Garre
May 22, 2021·Infectious Disease Clinics of North America·Julie M Steinbrink, Marisa H Miceli

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Methods Mentioned

BETA
PCR
bronchoalveolar lavage
ELISA
genetic modification

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