Pathologic and biological prognostic factors of breast cancers in short- and long-term hormone replacement therapy users

Annals of Surgical Oncology
Virgilio SacchiniUmberto Veronesi

Abstract

Breast cancer tumors occurring in hormone replacement therapy (HRT) users are less aggressive, but no studies have compared tumor aggressiveness among HRT users by length and mode of therapy. A total of 1105 consecutive postmenopausal patients treated for operable breast cancer at the European Institute of Oncology were identified. Women exposed to HRT were compared with HRT nonusers by clinical stage at presentation and pathologic and biological tumor characteristics. HRT duration and administration modality were analyzed in relation to tumor characteristics in the HRT group. Better stage distribution, including smaller pathologic tumor diameter and fewer involved axillary lymph nodes, was seen in the HRT group. Estrogen receptor-positive tumors were more frequent in the control group, but this tendency was reversed with longer exposure to HRT. Histological grade III tumors were less frequent in the HRT group. More favorable prognostic factors were associated with HRT >5 years. The proliferative fraction was higher in patients with exposure <1 vs. >5 years and in oral versus transdermal users. Breast cancers developing during HRT have better prognostic characteristics than those seen in HRT nonusers. A trend toward better prog...Continue Reading

References

Jul 1, 1992·Annals of Internal Medicine·E G LufkinB L Riggs
Aug 1, 1991·The Journal of Clinical Endocrinology and Metabolism·K A SteingoldS Reznikov
Nov 7, 1990·Journal of the National Cancer Institute·M PollakR Margolese
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Jul 1, 1995·British Journal of Cancer·C La VecchiaM Ferraroni
Mar 1, 1995·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·C CampagnoliP Sismondi
Oct 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·B R Westley, F E May
Jul 1, 1994·British Journal of Obstetrics and Gynaecology·A CheangG Samsioe
Dec 1, 1993·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·C CampagnoliP Sismondi
Jan 1, 1996·Breast Cancer Research and Treatment·C MagnussonI Persson
Sep 1, 1996·The American Journal of Surgical Pathology·C DoglioniG Viale
May 16, 1997·International Journal of Cancer. Journal International Du Cancer·Y A LuqmaniA H Parkar
Jun 19, 1997·The New England Journal of Medicine·F GrodsteinF E Speizer
Aug 22, 1997·International Journal of Cancer. Journal International Du Cancer·A MolinoG L Cetto
Dec 9, 1997·British Journal of Obstetrics and Gynaecology·E HirvonenG Wilén-Rosenqvist
Jun 30, 1998·International Journal of Cancer. Journal International Du Cancer·P BonnierP M Martin
Aug 12, 1998·The Journal of Steroid Biochemistry and Molecular Biology·O W PrallR L Sutherland
Sep 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K HolliJ Cuzick
Nov 3, 1998·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·C CampagnoliP Sismondi
Nov 10, 1998·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·T H LippertA O Mueck
Jun 15, 1999·JAMA : the Journal of the American Medical Association·S M GapsturT A Sellers

❮ Previous
Next ❯

Citations

Sep 23, 2008·Breast Cancer Research : BCR·Lena U RosenbergPer Hall
Aug 30, 2008·Pathology Oncology Research : POR·Blanca Murillo-OrtizLuis Benítez-Bribiesca
Dec 13, 2003·Maturitas·René Druckmann
Aug 8, 2006·Thyroid : Official Journal of the American Thyroid Association·Catharina Ihre Lundgren
Jan 19, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Délio Marques CondeElbio Cândido de Paula
Jun 10, 2011·The Breast : Official Journal of the European Society of Mastology·A K BaumgärtnerM Kiechle
Oct 1, 2013·Taiwanese Journal of Obstetrics & Gynecology·Fang-Ping ChenYuet-Tong Ng
Jan 11, 2007·International Journal of Cancer. Journal International Du Cancer·Umberto Veronesi, Stefano Zurrida
Sep 18, 2008·International Journal of Cancer. Journal International Du Cancer·Signe BorgquistGöran Landberg
Feb 6, 2007·International Journal of Cancer. Journal International Du Cancer·Signe BorgquistJonas Manjer
Jun 2, 2005·The Breast : Official Journal of the European Society of Mastology·A S FletcherD M Gertig
Jun 1, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·N BigliaP Sismondi
Dec 4, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Karla KerlikowskePatricia A Carney
Sep 25, 2003·Breast Cancer Research and Treatment·Dorota M GertigAnne M Kavanagh
Jan 16, 2014·The Journal of Clinical Endocrinology and Metabolism·Richard J SantenHugh S Taylor
Dec 31, 2003·Annals of Surgical Oncology·David J Winchester
Oct 11, 2007·Menopause : the Journal of the North American Menopause Society·Leon Speroff
Aug 1, 2018·Nature Communications·Marco Padilla-RodriguezGhassan Mouneimne
Sep 10, 2005·Human Reproduction Update·John A CollinsPier Giorgio Crosignani
Mar 4, 2005·Medical Informatics and the Internet in Medicine·Jens BuckschBernhilde Deitermann
Dec 31, 2003·Annals of Surgical Oncology·Itzhak PappoAriel Halevy
Apr 25, 2009·The Cancer Journal·Avrum Z Bluming, Carol Tavris

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.