Pathologic and immunologic profiles of a limited form of neuromyelitis optica with myelitis

Neurology
K YanagawaM Nishizawa

Abstract

Neuromyelitis optica (NMO) is a demyelinating syndrome characterized by myelitis and optic neuritis. Detection of anti-NMO immunoglobulin G antibody that binds to aquaporin-4 (AQP4) water channels allows the diagnosis of a limited form of NMO in the early stage with myelitis, but not optic neuritis. However, the detailed clinicopathologic features and long-term course of this limited form remain elusive. We investigated 8 patients with the limited form of NMO with myelitis in comparison with 9 patients with the definite form. All patients with limited and definite form showed uniform relapsing-remitting courses, with no secondary progressive courses. Pathologic findings of biopsy specimens from the limited form were identical to those of autopsy from the definite form, demonstrating extremely active demyelination of plaques, extensive loss of AQP4 immunoreactivity in plaques, and diffuse infiltration by macrophages containing myelin basic proteins with thickened hyalinized blood vessels. Moreover, the definite form at the nadir of relapses displayed significantly higher amounts of the inflammatory cytokines interleukin (IL)-1beta and IL-6 in CSF than the limited form and multiple sclerosis. This consistency of pathologic findin...Continue Reading

Citations

Jul 10, 2013·Journal of Neurology·Yára Dadalti FragosoFabio Siquineli
Jul 20, 2010·Nature Reviews. Neurology·Sven Jarius, Brigitte Wildemann
Feb 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Norio ChiharaTakashi Yamamura
Jan 17, 2013·Journal of Neuroinflammation·Sven Jarius, Brigitte Wildemann
Mar 5, 2011·Internal Medicine·Hideyuki MatsumotoHideji Hashida
Nov 16, 2011·Internal Medicine·Yuji TanakaTakashi Inuzuka
Sep 17, 2011·Rinshō shinkeigaku = Clinical neurology·Keiko Tanaka
Sep 17, 2011·Rinshō shinkeigaku = Clinical neurology·Izumi Kawachi
Apr 12, 2016·Multiple Sclerosis and Related Disorders·Adi Vaknin-DembinskyDimitrios Karussis
Jun 17, 2015·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Izumi Kawachi, Masatoyo Nishizawa
May 21, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Raja Sawaya, Wael Radwan
May 29, 2012·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Nicholas E MartinezIkuo Tsunoda
May 31, 2011·Autoimmunity Reviews·Andrea T Borchers, M Eric Gershwin
Nov 20, 2015·Neurology·Matthew M NourMaria Isabel Leite
Mar 17, 2010·Journal of Neuroimmunology·Harleen SainiMichael Levy
Feb 13, 2015·Rinshō shinkeigaku = Clinical neurology·Izumi KawachiMasatoyo Nishizawa
Oct 27, 2015·Frontiers in Immunology·Reza KhorooshiTrevor Owens
Feb 5, 2013·Annals of Neurology·Etsuji SajiIzumi Kawachi
Mar 10, 2016·The International Journal of Neuroscience·Jie LinJunhui Xia
Feb 3, 2016·Annals of Neurology·Mariko HokariIzumi Kawachi
Jun 1, 2015·Journal of the Neurological Sciences·Andrew MurchisonJacqueline Palace
Nov 5, 2013·Medical Hypotheses·S Jarius, B Wildemann
Feb 9, 2011·Journal of the Neurological Sciences·Sabrina Matà, Francesco Lolli
Dec 3, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Kuo-Hsuan ChangChiung-Mei Chen
Apr 16, 2016·Brain Pathology·Shotaro HayashidaJun-Ichi Kira
Jan 18, 2011·Multiple Sclerosis : Clinical and Laboratory Research·N CollonguesJ de Seze
Aug 27, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Akiyuki UzawaSatoshi Kuwabara
Mar 23, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Akiko YokosekiIzumi Kawachi
Jun 15, 2011·Multiple Sclerosis : Clinical and Laboratory Research·J L KitleyJ A Palace
Sep 28, 2016·Journal of Neurology, Neurosurgery, and Psychiatry·Izumi Kawachi, Hans Lassmann
Jun 26, 2014·Arquivos de neuro-psiquiatria·Yara Dadalti Fragoso
Sep 12, 2015·Multiple Sclerosis : Clinical and Laboratory Research·Yoko WarabiEiji Isozaki
Dec 24, 2010·Therapeutic Advances in Neurological Disorders·Romain MarignierJérôme Honnorat
Mar 8, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Mickael BonnanPhilippe Cabre
Apr 29, 2018·Journal of Neuroinflammation·Kazuya YamashitaTatsusada Okuno
Jun 24, 2017·Neurology. Neuroimmunology and Neuroinflammation·Anna GahlenIngo Kleiter

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.