Pathologic and mammographic findings predicting the adequacy of tumor excision before breast-conserving therapy

AJR. American Journal of Roentgenology
P J BeronF A Vicini

Abstract

We performed a retrospective review to determine the need for reexcision after excisional biopsy in patients with breast cancer who were treated with breast-conserving therapy. Eighty-seven patients with infiltrating ductal carcinoma of the breast underwent excisional biopsy followed by reexcision of the tumor site. Reexcision specimens were evaluated for residual disease and correlated with initial mammographic and pathologic findings. Tumors with an extensive intraductal component (EIC) were more likely to have residual disease at reexcision than those without an EIC (65% versus 6%, p < .01). Initially positive margins did not predict residual disease at reexcision significantly better than did initially negative margins (29% versus 13%, p = .08). Suspicious mammographic calcifications, absence of a discernible mass detected mammographically, or both were associated with a significantly increased risk of residual disease at reexcision. By combining all features (EIC, margin status, and mammography), we found that subsets of patients had significantly different risks of residual disease, which ranged from 6% to 83% (p < .01). Mammographic and pathologic findings are useful in predicting the adequacy of breast resection before ...Continue Reading

Citations

Jan 25, 2002·Annals of Surgery·Csaba GajdosAlfred W Rademaker
Feb 14, 2006·Annals of Surgical Oncology·Mary F DillonNiall O'Higgins
Oct 17, 2015·Annals of Surgical Oncology·Brandy L EdwardsAnneke T Schroen
Jul 14, 2012·The Breast : Official Journal of the European Society of Mastology·E A M O'FlynnM J Michell
Jul 9, 2005·Clinical Breast Cancer·Norma RodriguezElizabeth L Wiley
Nov 14, 2006·Magnetic Resonance Imaging Clinics of North America·Monica Morrow, Gary Freedman
May 30, 2006·International Journal of Radiation Oncology, Biology, Physics·Derek B ChismPenny R Anderson
Apr 9, 2005·International Journal of Radiation Oncology, Biology, Physics·Gary M FreedmanNicos Nicolaou
May 1, 2012·International Journal of Radiation Oncology, Biology, Physics·Brandon T NguyenBoon H Chua
Oct 2, 2001·The British Journal of Surgery·N CrombieI O Ellis
Jul 4, 2006·ANZ Journal of Surgery·Paul R B KitchenMichael A Henderson
Oct 13, 1998·The Australian and New Zealand Journal of Surgery·J KolliasE Vernon-Roberts
Jan 28, 2003·The American Journal of Surgical Pathology·Elizabeth L WileyMonica Morrow
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G LiljegrenH O Adami

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.