Pathologic audit of 164 consecutive cases of vulvar intraepithelial neoplasia

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
James ScurryNeville Hacker

Abstract

There are 2 types of vulvar intraepithelial neoplasia (VIN): warty-basaloid and differentiated. Differentiated VIN is uncommon and seldom diagnosed prior to carcinoma and, traditionally, is not graded. There are currently 3 grading systems for warty-basaloid VIN: the World Health Organization (WHO) 3 grade system of VIN 1-3, a 2 grade system of low and high grade vulvar intraepithelial lesions, and the revised International Society for the Study of Vulvovaginal Disease (ISSVD) classification which has no grading of VIN. According to the ISSVD, VIN 1 should be abolished and VIN 2 and 3 combined into a single category, simply termed warty-basaloid VIN. To determine the best system for grading warty-basaloid VIN and learn more about differentiated VIN, we reviewed the pathology of 164 consecutive women with VIN. Of these, 134 (82.3%) had warty-basaloid VIN, 29 (18.2%) had differentiated VIN, and 1 had both. Of warty-basaloid VIN cases, 4 had VIN 1, 13 VIN 2, and 118 VIN 3 when graded according to the WHO. All VIN 1 occurred in condylomata acuminata. VIN 2 and 3 were distinguished only by degree of abnormality. Differentiated VIN was diagnosed before SCC in only 7 cases (26.7%). Because the only VIN 1 cases seen were in condylomata...Continue Reading

References

Sep 1, 1983·Clinical and Experimental Dermatology·I S Jones
Apr 1, 1997·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·M J KagieG J Fleuren
Feb 26, 2000·Journal of Clinical Pathology·M van BeurdenF J ten Kate
Feb 24, 2001·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·W R Hart
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·J. Scurry
Dec 12, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·K J RolfeC W Perrett
Nov 26, 2002·The Journal of Investigative Dermatology·Katrina VaninRobert G Ramsay
Dec 24, 2002·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Christopher P Crum
Jul 15, 1961·British Medical Journal·T N JEFFCOATE, A S WOODCOCK
Dec 17, 2003·British Journal of Cancer·K J RolfeC W Perrett

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Citations

Nov 9, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Hedwig P van de NieuwenhofLeon C L T van Kempen
Feb 2, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Loes C G van den EindenJohan Bulten
Jun 22, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Andres A Roma, William R Hart
Apr 28, 2011·The American Journal of Dermatopathology·Janis M TaubeSoheil S Dadras
Sep 29, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Fani KokkaAdam N Rosenthal
Jan 9, 2014·Journal of Clinical Pathology·M Carolina Reyes, Kumarasen Cooper
Jan 21, 2012·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Xiaochuan LiJinghe Lang
Mar 1, 2011·Surgical Pathology Clinics·Edyta C Pirog
Apr 15, 2008·Critical Reviews in Oncology/hematology·H P van de NieuwenhofJ A de Hullu
Aug 12, 2014·Best Practice & Research. Clinical Obstetrics & Gynaecology·Mario PretiLeonardo Micheletti
Dec 28, 2016·Journal of Lower Genital Tract Disease·Raquel Camara RiveroEdison Capp
Oct 17, 2015·International Journal of STD & AIDS·M TobyF Lewis
Jun 11, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Lois J EvaDavid M Luesley
Jul 24, 2013·Expert Review of Anticancer Therapy·Loes Cg van den EindenJoanne A de Hullu
Mar 15, 2016·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Susan M BigbyRonald W Jones
Jun 7, 2011·Journal of Clinical Pathology·José Carlos SadallaJesus Paula Carvalho
Sep 7, 2018·Virchows Archiv : an International Journal of Pathology·Shatavisha DasguptaSenada Koljenović
Jun 8, 2017·Advances in Anatomic Pathology·Natalia RakislovaJaume Ordi
Oct 27, 2020·Journal of Lower Genital Tract Disease·Debra S HellerUNKNOWN ISSVD Difficult Pathologic Diagnoses Committee

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