Pathologic categorization of lung nodules: Radiomic descriptors of CT attenuation distribution patterns of solid and subsolid nodules in low-dose CT

European Journal of Radiology
Chuan ZhouJun Wei

Abstract

Develop a quantitative image analysis method to characterize the heterogeneous patterns of nodule components for the classification of pathological categories of nodules. With IRB approval and permission of the National Lung Screening Trial (NLST) project, 103 subjects with low dose CT (LDCT) were used in this study. We developed a radiomic quantitative CT attenuation distribution descriptor (qADD) to characterize the heterogeneous patterns of nodule components and a hybrid model (qADD+) that combined qADD with subject demographic data and radiologist-provided nodule descriptors to differentiate aggressive tumors from indolent tumors or benign nodules with pathological categorization as reference standard. The classification performances of qADD and qADD + were evaluated and compared to the Brock and the Mayo Clinic models by analysis of the area under the receiver operating characteristic curve (AUC). The radiomic features were consistently selected into qADDs to differentiate pathological invasive nodules from (1) preinvasive nodules, (2) benign nodules, and (3) the group of preinvasive and benign nodules, achieving test AUCs of 0.847 ± 0.002, 0.842 ± 0.002 and 0.810 ± 0.001, respectively. The qADD + obtained test AUCs of 0.8...Continue Reading

References

Mar 1, 1979·Investigative Radiology·J A Swets
Jan 21, 1995·BMJ : British Medical Journal·J M Bland, D G Altman
Apr 18, 2001·Journal of Clinical Pathology·K M Kerr
Feb 21, 2004·Critical Care : the Official Journal of the Critical Care Forum·Viv BewickJonathan Ball
Jan 24, 2007·AJR. American Journal of Roentgenology·Myria PetrouLaurence H Baker
Mar 21, 2007·Academic Radiology·Iva PetkovskaDenise R Aberle
Feb 7, 2008·IEEE Transactions on Neural Networks·O ChapelleV N Vapnik
Jan 22, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisDavid Yankelewitz
Jul 21, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Erik ThunnissenDirk Joop Kuik
Sep 6, 2013·The New England Journal of Medicine·Annette McWilliamsStephen Lam
Dec 19, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kyung Hee LeeSang Min Lee
Feb 22, 2014·AJR. American Journal of Roentgenology·Ho Yun LeeJung Won Moon
Apr 23, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Tetsuya IsakaMunetaka Masuda
Jun 4, 2014·Nature Communications·Hugo J W L AertsPhilippe Lambin
Jan 17, 2015·Physics in Medicine and Biology·B C LassenE M van Rikxoort

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