Pathologic changes during acute Q fever: influence of the route of infection and inoculum size in infected guinea pigs.

Infection and Immunity
B La ScolaD Raoult

Abstract

As assessed by both standard histological staining and immunochemistry, intraperitoneal inoculation of C. burnetii in guinea pigs led to pathologic changes mainly in the liver, whereas intranasal inoculation led to pathologic changes mainly in the lungs. Myocarditis and positive blood cultures were observed only in those animals which received the highest inoculum. We therefore conclude that both the route of infection and the size of the inoculum influence clinical expression in acute Q fever.

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Citations

Feb 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Anders OmslandRobert A Heinzen
May 19, 2010·Epidemiology and Infection·C C van den WijngaardM P G Koopmans
Dec 24, 2011·International Journal of Microbiology·Sarah Rebecca PorterClaude Saegerman
Sep 14, 2007·Scandinavian Journal of Infectious Diseases·Chung-Hsu LaiHsi-Hsun Lin
Oct 24, 2006·Infection and Immunity·K E Russell-LodrigueJ E Samuel
Feb 17, 2006·Annals of the New York Academy of Sciences·K E Russell-LodrigueJ E Samuel
Jun 7, 2011·Annual Review of Microbiology·Anders Omsland, Robert A Heinzen
Aug 21, 2010·Risk Analysis : an Official Publication of the Society for Risk Analysis·Sushil B TamrakarTimothy A Bartrand
Jan 3, 2013·Cellular Microbiology·Joseph G GrahamDaniel E Voth
Dec 19, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hervé Tissot-DupontDidier Raoult
Feb 24, 2006·Infection and Immunity·Amélie HonstettreJean-Louis Mege
Mar 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amélie HonstettreJean-Louis Mege
Oct 30, 2010·Journal of Medical Microbiology·P C F Oyston, C Davies
Apr 24, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P E FournierD Raoult
Jan 6, 2016·Canadian Journal of Microbiology·Samira BoarbiMarcella Mori
Mar 27, 2007·Cellular Microbiology·Daniel E Voth, Robert A Heinzen
Mar 19, 2014·The American Journal of Tropical Medicine and Hygiene·Sophie EdouardDidier Raoult
Apr 11, 2003·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J M RolainD Raoult
May 19, 2000·Microbes and Infection·L Norlander
Jul 3, 1998·Journal of Clinical Microbiology·P E FournierD Raoult
Oct 9, 1999·Clinical Microbiology Reviews·M Maurin, D Raoult
Mar 29, 2005·The Lancet Infectious Diseases·D RaoultJl Mege
Oct 31, 2009·Veterinary Microbiology·Emmanouil Angelakis, Didier Raoult

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