Pathologic changes in the non-carcinomatous epithelium of the gallbladder in patients with a relatively long common channel

Gastrointestinal Endoscopy
Terumi KamisawaToshikazu Yamaguchi

Abstract

Except for pancreaticobiliary maljunction, the relationship between a relatively long common channel and gallbladder carcinoma is unknown. For purposes of this study, a high confluence of pancreaticobiliary ducts was defined as a common channel that is 6 mm or greater in length, together with occlusion of the communication between the pancreatic and bile ducts during sphincter contraction. Pancreaticobiliary maljunction and high confluence of the pancreaticobiliary ducts were detected in 69 (2.1%) and 54 (1.6%), respectively, of 3300 consecutive patients who underwent ERCP. Proliferation activity and genetic alteration were examined in the non-carcinomatous epithelium of the gallbladder in patients with these two radiographic findings at ERCP. The Ki-67 labeling index in the epithelium in cases of a high confluence of the pancreaticobiliary ducts and pancreaticobiliary maljunction without biliary dilatation was significantly greater than that in cases of gallbladder carcinoma without these anomalies (p < 0.01). Overexpression of p53 and K-ras mutations were detected in, respectively, 22.2% and 27.8% of cases of a high confluence of pancreaticobiliary ducts. A relatively long common channel may be an important risk factor for th...Continue Reading

References

Mar 14, 1998·Journal of Cancer Research and Clinical Oncology·R BrollM Duchrow
Aug 6, 1998·The British Journal of Surgery·M Sugiyama, Y Atomi
Oct 20, 1999·Journal of Hepato-biliary-pancreatic Surgery·K HanadaG Kajiyama
May 22, 2002·Journal of Hepato-biliary-pancreatic Surgery·Yoshiro MatsumotoKohichi Suda
Jul 19, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Terumi KamisawaAkihiro Munakata
Sep 28, 2002·Journal of Hepato-biliary-pancreatic Surgery·Toshiki MatsubaraTakahiko Funabiki
Feb 1, 1962·Archives of Surgery·G S DOWDYW G BROWN

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Citations

Sep 7, 2006·Abdominal Imaging·Terumi KamisawaMasakatsu Matsukawa
May 27, 2008·Langenbeck's Archives of Surgery·Takahiko FunabikiShin Ishihara
Dec 27, 2008·Journal of Hepato-biliary-pancreatic Surgery·Terumi KamisawaAtsutake Okamoto
Feb 14, 2009·Journal of Hepato-biliary-pancreatic Surgery·Terumi KamisawaNobuaki Funata
Mar 23, 2005·Pancreas·Terumi KamisawaMasakatsu Matsukawa
Nov 27, 2008·World Journal of Gastroenterology : WJG·Terumi KamisawaKouji Tsuruta
Jun 23, 2012·Journal of Gastroenterology·Terumi KamisawaUNKNOWN Japanese Study Group on Pancreaticobiliary Maljunction
Jun 6, 2013·Journal of Gastroenterology·Jun HoraguchiUNKNOWN committee of Diagnostic Criteria of The Japanese Study Group on Pancreaticobiliary Maljunction
Dec 5, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Terumi KamisawaTsuneo Sasaki
Dec 19, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·T KamisawaA Okamoto
Apr 16, 2010·Journal of Hepato-biliary-pancreatic Sciences·Terumi KamisawaUNKNOWN Committee of Diagnostic Criteria of The Japanese Study Group on Pancreaticobiliary
Jun 27, 2013·Journal of Hepato-biliary-pancreatic Sciences·Terumi KamisawaMasaru Miyazaki
Nov 19, 2014·Journal of Gastroenterology·Terumi KamisawaTakao Itoi
Oct 6, 2016·Journal of Gastroenterology·Terumi KamisawaMasataka Kikuyama
Nov 11, 2020·World Journal of Surgical Oncology·Toshimitsu IwasakiYoji Kishi

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