PMID: 6629890Oct 1, 1983Paper

Pathologic effects of fractionated fast neutrons or photons on the pancreas, pylorus and duodenum of dogs

International Journal of Radiation Oncology, Biology, Physics
B C ZookC C Rogers

Abstract

Thirty-nine adult male Beagles received either fast neutron or photon irradiation to the right thorax to determine the relative biological effectiveness (RBE) of fast neutrons on normal pulmonary tissue. The right anterior abdomen was included in the field of radiation. Twenty-four dogs (six/group) received fast neutrons with an average energy of 15 MeV to total doses of 1000, 1500, 2250 or 3375 rad in four fractions per week for six weeks. Fifteen dogs received 3000, 4500 or 6750 rad of photons (five/group) in an identical fractionation pattern. All neutron irradiated dogs receiving 3375 and 2250 rad and one receiving 1500 rad developed clinical signs of pancreatic, hepatic and gastrointestinal disturbances. The liver enzymes of these dogs became elevated and they died or were euthanatized in extremis 47-367 days after irradiation. Only one 6750 rad photon dog developed similar signs and died 708 days post-irradiation. Five neutron and 10 photon exposed dogs died of other causes. Neutron-induced lesions in the stomach and duodenum included hemorrhages, erosions, ulcerations and fibrosis. Ulcers perforated the GI tract of five dogs. Pancreatic lesions included degranulation and necrosis of acinar cells, fibrosis ans atrophy. Is...Continue Reading

References

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Citations

Mar 2, 2002·International Journal of Radiation Oncology, Biology, Physics·Eckehard HorstNormann A Willich
Sep 25, 2001·Micron : the International Research and Review Journal for Microscopy·Agnes TelbiszZoltán Somosy
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·B C ZookC C Rogers
Nov 14, 2007·Methods in Enzymology·J Martin Brown
Jun 15, 2018·Journal of Radiation Research·Sei Hwan YouChang Geol Lee

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