Pathologic explanation for postoperative obstipation in Hirschsprung's disease revealed with monoclonal antibody staining

American Journal of Clinical Pathology
P KlückJ C Molenaar

Abstract

Until now, no pathologic explanation could be found for the postoperative obstipation occurring in some patients with intestinal aganglionosis. Twenty-two of 108 infants treated for intestinal aganglionosis suffered from postoperative obstipation. Resected material from these 22 patients and from 17 control subjects was investigated with monoclonal anti-neurofilament antibody staining. An abnormal staining pattern was revealed in 18 of the constipated patients. Consequently, this new immunohistochemical staining technic has revealed a hitherto unsuspected cause for postoperative obstipation in aganglionosis. The monoclonal antibody may provide early warning of such postoperative constipation.

Citations

Sep 1, 1992·The Journal of Pathology·V R SamsJ Keeling
Jul 1, 1988·Histopathology·P Klück, F J ten Kate
May 1, 1993·World Journal of Surgery·P Puri

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