Abstract
For hepatocellular carcinoma, the peak age of patients is at the sixth decade. However, the influence of age on the tumor biologic behavior and long-term patient survival is controversial. We retrospectively studied 278 patients whose hepatocellular carcinomas were surgically resected to analyze the pathologic and clinical features of the tumors and patient survival in relation to age. The patients were divided into two groups, younger than 50 years of age and older than 50 years. Ninety-seven patients were 50 years of age or under, and 181 were older than 50 years. The younger patients had: (1) more frequent hepatitis B surface antigen positivity (P = 0.022), (2) less cirrhosis (P = 0.050), (3) less tumor encapsulation, (4) a more advanced tumor stage in terms of more venous permeation (P = 0.012), more liver invasion (P = 0.010) and larger tumor (P = 0.002), and (5) a more frequently raised serum alpha-fetoprotein level (P = 0.035). In spite of the more advanced stage of the tumors, both the actuarial and disease-free survival rates did not differ significantly from those of the older group. The operative mortality rates also were similar in both groups. To conclude, there were distinct differences in the clinical and patholo...Continue Reading
References
Jan 1, 1979·Acta Radiologica: Oncology, Radiation, Physics, Biology·G NémethL Takácsi-Nagy
Jul 1, 1992·Cancer·I O NgS T Fan
Mar 1, 1992·Journal of Surgical Oncology·R IzumiI Miyazaki
Apr 1, 1992·Journal of Clinical Gastroenterology·T HaradaM Okazaki
Jul 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S OkadaK Aoki
Aug 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y AkashiK Inoue
Mar 1, 1991·World Journal of Surgery·B RingeG Tusch
May 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E C LaiJ Wong
Dec 1, 1990·Cancer·T FurutaK Sugimachi
Mar 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T MatsumataK Sugimachi
Feb 1, 1983·Cancer·K KishiM Makuuchi
Jul 1, 1994·Archives of Surgery·M F ChenS C Chen
Sep 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J BruixL Boix
Nov 1, 1993·Cancer·Y Z PattB Levin
Feb 1, 1995·Archives of Surgery·S T FanJ Wong
Oct 1, 1994·British Journal of Cancer·F NomuraK Okuda
Aug 1, 1994·Archives of Surgery·K TakenakaK Sugimachi
Apr 1, 1994·Annals of Surgery·N YamanakaF Tomoda
Nov 1, 1993·Gastroenterology·N NagasueT Nakamura
Apr 1, 1993·Annals of Surgery·N NagasueH Yukaya
Sep 1, 1993·Cancer·F TrevisaniL Fornalè
May 1, 1954·Cancer·H A EDMONDSON, P E STEINER
Citations
Mar 27, 2004·Alimentary Pharmacology & Therapeutics·C-M LamS T Fan
May 15, 2007·Journal of Gastroenterology and Hepatology·Soo-Jeong ChoHyo-Suk Lee
Feb 1, 2011·Journal of the American Geriatrics Society·Sang Hyub LeeSung Gwon Kang
Aug 28, 2018·Expert Review of Gastroenterology & Hepatology·Ling-Yun ZhaoJian-Hong Zhong
Feb 23, 2007·The American Journal of Gastroenterology·Franco TrevisaniUNKNOWN Italian Liver Cancer (ITA.LI.CA) Group
Nov 18, 2008·Journal of Gastroenterology·Pik-Eu ChangChee-Kiat Tan
Mar 8, 2011·World Journal of Surgery·Kazuki TakeishiYoshihiko Maehara
Jul 20, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Cho Rok LeeKyung Sik Kim
Aug 24, 2012·Journal of Clinical Gastroenterology·Ina M NiederleArndt Weinmann
Sep 5, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Fumitoshi HirokawaKazuhisa Uchiyama
Mar 21, 2021·American Journal of Surgery·Yong-Kang DiaoTian Yang