Pathologic Finding of Thymic Carcinoma Accompanied by Myasthenia Gravis

Journal of Clinical Neurology
Se Hoon KimYang Ki Minn

Abstract

The World Health Organization (WHO) has classified thymic carcinoma and other thymomas (types A, AB, and B) as different neoplasms. Myasthenia gravis (MG) is an early sign of thymoma and theoretically does not accompany thymic carcinoma; however, cases of thymic carcinoma with MG have been reported. Whether thymic carcinoma can accompany MG has yet to be established. The medical records of patients who underwent thymectomy for MG between 1990 and 2011 in a single hospital were reviewed. All cases with the diagnostic code of "thymic carcinoma" or "thymoma type C" (old terminology) were selected. A pathologist re-reviewed the pathologic specimens using the new WHO criteria. The rate of thymic carcinoma among these MG patients was then calculated. A total of 81 patients with MG had thymic tumors, 10 of whom had thymic carcinomas or thymoma type C. Seven cases of well-differentiated thymic carcinomas (type B3) were excluded, leaving three (3.7%) cases of thymic carcinoma with MG. All three of these cases were type B3 thymoma with a focal squamous cell carcinoma component that was very small and well demarcated. In addition, two out of the three tumors were found to be at an early clinical stage. All of the cases survived without re...Continue Reading

References

Dec 1, 1992·The American Journal of Surgical Pathology·T KirchnerH K Müller-Hermelink
Dec 16, 1998·The American Journal of Surgical Pathology·T T Kuo, J K Chan
Jul 6, 2000·The American Journal of Pathology·A ZettlA Marx
Oct 21, 2003·The Journal of Thoracic and Cardiovascular Surgery·Kazuo NakagawaRyosuke Tsuchiya
Sep 22, 2005·Surgery Today·Philipp StröbelHans Konrad Müller-Hermelink
Mar 27, 2010·The Annals of Thoracic Surgery·Seth D Goldstein, Stephen C Yang
Apr 13, 2010·Autoimmunity·A MarxP Ströbel
Oct 5, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Philipp StröbelAlexander Marx
Nov 26, 2010·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Enrico RuffiniAlberto Oliaro
Sep 1, 2011·Annals of Surgical Oncology·Lei YuMark J Krasna
Feb 18, 2012·American Journal of Clinical Pathology·Cesar A MoranSaul Suster
Aug 23, 2012·PloS One·Sunil BadvePatrick J Loehrer
Jan 15, 2013·The Journal of Thoracic and Cardiovascular Surgery·Giuseppe MarulliFederico Rea
May 15, 2013·Journal of the National Comprehensive Cancer Network : JNCCN·David S EttingerUNKNOWN National Comprehensive Cancer Network
Dec 3, 2013·The Journal of Thoracic and Cardiovascular Surgery·Bo YeHeng Zhao
Dec 11, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Yong Won SeongYoung Tae Kim
Jun 8, 2014·Medical Oncology·J SyriosA E Athanasiou

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Citations

Sep 7, 2016·International Journal of Surgery Case Reports·Nobuyasu KuriharaYoshihiro Minamiya
Sep 24, 2020·The Thoracic and Cardiovascular Surgeon Reports·Daniel Thomas Pereira LopesEduardo Paula Estephan

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