Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging system.

Journal of the American Academy of Dermatology
Bianca D LemosPaul Nghiem

Abstract

The management of Merkel cell carcinoma (MCC) has been complicated by a lack of detailed prognostic data and by the presence of conflicting staging systems. We sought to determine the prognostic significance of tumor size, clinical versus pathologic nodal evaluation, and extent of disease at presentation and thereby derive the first consensus staging/prognostic system for MCC. A total of 5823 prospectively enrolled MCC cases from the National Cancer Data Base had follow-up data (median 64 months) and were used for prognostic analyses. At 5 years, overall survival was 40% and relative survival (compared with age- and sex-matched population data) was 54%. Among all MCC cases, 66% presented with local, 27% with nodal, and 7% with distant metastatic disease. For cases presenting with local disease only, smaller tumor size was associated with better survival (stage I, ≤2 cm, 66% relative survival at 5 years; stage II, >2 cm, 51%; P < .0001). Patients with clinically local-only disease and pathologically proven negative nodes had better outcome (76% at 5 years) than those who only underwent clinical nodal evaluation (59%, P < .0001). The National Cancer Data Base does not capture disease-specific survival. Overall survival for patien...Continue Reading

References

Dec 1, 1991·Archives of Surgery·A YiengpruksawanW K Knapper
Jan 29, 1999·Annals of Surgery·P J AllenD G Coit
Aug 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C M BalchA Morabito
Feb 21, 2002·Lancet·Eric A EngelsRobert W Miller
May 16, 2002·Seminars in Urologic Oncology·James A EasthamPeter T Scardino
Aug 19, 2003·Seminars in Surgical Oncology·Leslie H Sobin
Oct 25, 2003·Journal of the American Academy of Dermatology·Maria Agelli, Limin X Clegg
Dec 26, 2003·Statistics in Medicine·Paul W DickmanTimo Hakulinen
Dec 22, 2004·Journal of Surgical Oncology·Nicole C Hodgson
Apr 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter J AllenDaniel G Coit
Dec 14, 2006·Head & Neck·Jonathan R ClarkPatrick J Gullane
Aug 19, 2007·The Journal of Investigative Dermatology·Bianca Lemos, Paul Nghiem
Jan 10, 2008·Annals of Surgical Oncology·Karl Y BilimoriaClifford Y Ko
Jan 19, 2008·Science·Huichen FengPatrick S Moore
Feb 19, 2008·Journal of the American Academy of Dermatology·Michelle HeathPaul Nghiem
Sep 18, 2008·Cancer·Aleodor A AndeaKlaus J Busam
Jan 27, 2009·Journal of Surgical Oncology·Frederick L Greene, Leslie H Sobin
Jul 30, 2009·Journal of Cutaneous Pathology·Jorge Albores-SaavedraDonald Earl Henson
Mar 4, 2010·Archives of Pathology & Laboratory Medicine·Priya RaoDavid P Frishberg
Oct 15, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J C Becker
Apr 27, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John F ThompsonVernon K Sondak

❮ Previous
Next ❯

Citations

Jun 26, 2013·Wiener medizinische Wochenschrift·José Carlos CardosoUwe Wollina
Feb 26, 2013·Current Treatment Options in Oncology·Natalie J MillerPaul Nghiem
May 29, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Isabel Prieto MuñozAna M Pérez Casas
Jul 19, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sofia AsioliGianni Bussolati
Jul 14, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T JouaryUNKNOWN Groupe de Cancérologie Cutanée of the Société Française de Dermatologie
Jan 12, 2012·Current Opinion in Oncology·David SchramaJürgen C Becker
Mar 23, 2011·American Journal of Clinical Oncology·Emma RamahiTony Y Eng
May 1, 2013·Plastic and Reconstructive Surgery·Alex Senchenkov, Steven L Moran
Aug 26, 2011·Annals of Surgery·Ryan C FieldsDaniel G Coit
Feb 8, 2013·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Kyle AmberKeyvan Nouri
Jun 20, 2013·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Sherrif F IbrahimSiegrid S Yu
Dec 11, 2013·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Julie R Howle, Michael J Veness
Mar 30, 2012·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Leonid IziksonNathalie C Zeitouni
Sep 2, 2011·Clinical and Vaccine Immunology : CVI·Raphael P ViscidiDaniela Rivanera
Aug 10, 2012·Annals of Surgical Oncology·Ryan C Fields, Daniel G Coit
Jul 25, 2012·Annals of Surgical Oncology·Vernon K SondakJane L Messina
Dec 5, 2012·Annals of Surgical Oncology·Juan A Santamaria-BarriaJames C Cusack
Mar 12, 2013·Journal of Skin Cancer·Marie-Laure Matthey-GièMaurice Matter
Mar 12, 2013·Journal of Skin Cancer·Laura Desch, Rainer Kunstfeld
Feb 6, 2014·British Journal of Cancer·S LauttiaH Joensuu
Mar 19, 2014·Journal of Skin Cancer·Loren MastersonGeorge D Wilson
Jun 26, 2014·Cancers·Rachel WheatDavid J Blackbourn
Jan 1, 2014·Annals of Surgical Oncology·Swapnil D KachareTimothy L Fitzgerald
May 14, 2014·Cancers·Helen MerrittBita Esmaeli
Apr 15, 2014·Endocrine Pathology·Sofia AsioliVincenzo Eusebi
Sep 23, 2014·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·F KleffnerM Schlaak
Jul 31, 2014·Der Pathologe·I Fried, L Cerroni
Jul 31, 2014·Journal of the American Podiatric Medical Association·Dominic J RodaLinda Zhou
Jan 11, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Patrick J CiminoEric J Duncavage
Jun 28, 2011·Annales de dermatologie et de vénéréologie·O BoccaraUNKNOWN Groupe de cancérologie cutanée de la Société française de dermatologie
Mar 23, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kelly G PaulsonPaul Nghiem
Dec 2, 2015·Oncology Letters·Nikolaos KritikosEleni Sarafianou
Jan 3, 2016·Archivos de la Sociedad Española de Oftalmología·B RiescoN Saldías
Nov 26, 2015·American Journal of Clinical Dermatology·Grace C BrummerGlen M Bowen
Nov 7, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jennifer S KoSteven D Billings
Feb 14, 2014·Journal of the American Academy of Dermatology·Jayasri G IyerPaul Nghiem

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.