PMID: 25735340Mar 5, 2015Paper

Pathologic response during chemo-radiotherapy and variation of serum VEGF levels could predict effects of chemo-radiotherapy in patients with esophageal cancer

Asian Pacific Journal of Cancer Prevention : APJCP
Jing-Ping YuSu-Ping Sun

Abstract

To investigate the relationship between pathologic tumor response to concurrent chemo- radiotherapy and variation of serum VEGF in patients with esophageal cancer. Forty six patients with esophageal cancer who were treated with concurrent chemo-radiotherapy were enrolled. Endoscopic and pathologic examination was conducted before and four weeks afterwards. Serum level of VEGF was documented before, four weeks later and after chemo-radiotherapy. The relationship between pathologic response and the variation of serum level of VEGF and its influence on the prognosis were investigated. Serum level of VEGF decreased remarkably during and after chemo-radiotherapy in patients whose pathologic response was severe (F=5.393, 4.587, P(0.05). There were no statistical differences of serum VEGF level before, during and after chemo-radiotherapy for patients whose pathologic response was moderate or mild. There were 18 (85.7%), 7 (53.8%) and 6 patients (50.0%) whose serum VEGF level dropped in the severe, moderate and mild group, respectively, with significant differences among these groups (p=0.046). Two year survival rates of patients with severe, moderate and mild pathologic response were 61.9%, 53.8% and 33.3% respectively, and no statist...Continue Reading

References

Oct 12, 2002·Carcinogenesis·Yasuyuki ShibataYoshitaka Fujii
Nov 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gilles CrehangeUNKNOWN Federation Francophone de Cancerologie Digestive 9102
Jan 14, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael StahlHansjochen Wilke
May 5, 2011·Cancer Biotherapy & Radiopharmaceuticals·Jingping YuSuping Sun
Aug 9, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Cristina AngelescuAdrian Săftoiu
Sep 22, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Jian-Tao JiangSheng Chen
Dec 24, 2013·Cancer Treatment Reviews·Gabriel Limaverde-SousaCarlos Gil Ferreira
May 13, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Vikas Kumar SrivastavaMadan Lal Brahma Bhatt
Oct 24, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Guang-Yu TianXin-En Huang
Dec 19, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Ya-Dong QianXin-En Huang

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Citations

Oct 7, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Wei WeiYufeng Cheng
Jun 23, 2016·Journal for Immunotherapy of Cancer·Vishwajith SridharanJonathan D Schoenfeld
Mar 22, 2019·The Cancer Journal·Mohammad K KhanStephen J Kron

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