Pathologic splenic rupture as the presentation of mantle cell lymphoma

Leukemia & Lymphoma
A H StricklandR M Lowenthal

Abstract

Pathologic splenic rupture in non-Hodgkin's lymphoma (NHL) is a rare event, with 32 cases previously reported. Initial presentation of NHL with this complication is even rarer. We report such a case in an 80-year-old man with mantle cell lymphoma (MCL). It is notable that of the previously reported cases of pathologic rupture, three have occurred in MCL, suggesting that patients with this uncommon subtype of NHL may be particularly vulnerable to pathologic splenic rupture. Following splenectomy the patient's disease behaved in a high-grade fashion. Despite an initially encouraging response, his disease ran an aggressive course and he succumbed within four months. This case demonstrates the presentation of MCL with pathologic splenic rupture, as well as the potentially highly malignant behaviour of the disease.

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Citations

Aug 30, 2002·British Journal of Haematology·Rosa RuchlemerDaniel Catovsky
Oct 8, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Julie Teruya-FeldsteinCraig H Moskowitz
Aug 15, 2012·BMC Emergency Medicine·F Kris Aubrey-Bassler, Nicholas Sowers
Sep 27, 2003·The British Journal of Radiology·C GörgG Zugmaier
May 12, 2012·Case Reports in Medicine·Christopher B TanPaul Mustacchia

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