Pathologic substrates of focal epilepsy influence the generation of high-frequency oscillations

Epilepsia
Taissa Ferrari-MarinhoJean Gotman

Abstract

Although a clear correlation has been observed between high-frequency oscillations (HFOs) and the seizure-onset zone in distinct lesions, the role of the underlying pathologic substrates in the generation of HFOs is not well established. We aimed to investigate HFO correlates of different pathologic substrates in patients with drug-resistant epilepsy, and to examine the relation of HFOs with the anatomic location of the dysplastic lesion and surrounding tissue in patients with focal cortical dysplasia (FCD). We studied consecutive patients with drug-resistant epilepsy who underwent intracranial electroencephalography (iEEG) investigations with depth electrodes at the Montreal Neurological Institute and Hospital, between November 2004 and May 2013. Inclusion criteria were the following: a focal lesion documented by magnetic resonance imaging (MRI); EEG recording at a 2,000 Hz sampling rate; and seizures starting from depth electrode contacts placed in lesion and perilesional tissue. Thirty-seven patients (13 FCD, 12 mesial temporal sclerosis, five cortical atrophy, three polymicrogyria, three nodular heterotopia, and one tuberous sclerosis) were included; 18 were women (median age 34). Ripples and fast ripples were found in all ...Continue Reading

References

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Citations

Oct 6, 2015·Epilepsia·Renzo GuerriniIngmar Blumcke
Apr 6, 2017·Annals of Neurology·Maryse A van 't KloosterMaeike Zijlmans
Jul 1, 2017·Epilepsia·Birgit FrauscherJean Gotman
May 31, 2017·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Daisuke HirozawaYushi Inoue
Jan 24, 2018·Brain : a Journal of Neurology·Karina A González OtárulaJean Gotman
Oct 7, 2017·Epilepsia·Francesca PizzoFabrice Bartolomei
Mar 26, 2019·Brain : a Journal of Neurology·Mark A KramerCatherine J Chu
Jul 14, 2018·Frontiers in Neurology·Aaron M SpringPaolo Federico
Jun 24, 2017·Neurologia Medico-chirurgica·Koji Iida, Hiroshi Otsubo
Sep 5, 2019·Journal of Epilepsy Research·Chae Jung Park, Seung Bong Hong
Jun 12, 2020·Epilepsia Open·Krit CharupanitBeth A Lopour
Dec 20, 2018·Epilepsia Open·Jerome EngelRichard Staba
Apr 9, 2019·Epilepsy Currents·David King-Stephens
Oct 22, 2020·Epilepsy Currents·Julia Jacobs, Maeike Zijlmans
Jan 11, 2021·Epilepsy Research·Miguel Arévalo-AstradaJorge G Burneo
Jun 2, 2020·Neurosurgery Clinics of North America·Niravkumar Barot
Apr 10, 2021·Expert Review of Neurotherapeutics·Renzo Guerrini, Carmen Barba
Jun 26, 2021·Frontiers in Human Neuroscience·Xiaonan LiXiaofeng Yang
Sep 29, 2020·Seizure : the Journal of the British Epilepsy Association·Asumi OriharaTaketoshi Maehara

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