Pathological alteration in the choroid plexus of Alzheimer's disease: implication for new therapy approaches.

Frontiers in Pharmacology
Agnieszka Krzyzanowska, Eva Carro

Abstract

Morphological alterations of choroid plexus in Alzheimer's disease (AD) have been extensively investigated. These changes include epithelial atrophy, thickening of the basement membrane, and stroma fibrosis. As a result, synthesis, secretory, and transportation functions are significantly altered resulting in decreased cerebrospinal fluid (CSF) turnover. Recent studies discuss the potential impacts of these changes, including the possibility of reduced resistance to stress insults and slow clearance of toxic compounds from CSF with specific reference to the amyloid peptide. Here, we review new evidences for AD-related changes in the choroid plexus. The data suggest that the significantly altered functions of the choroid plexus contribute to the multiparametric pathogenesis of late-onset AD.

Citations

Mar 11, 2015·Journal of Neuropathology and Experimental Neurology·Agnieszka KrzyzanowskaEva Carro
Feb 24, 2015·Frontiers in Cellular Neuroscience·Ibrahim González-MarreroRafael Castro-Fuentes
Jun 4, 2014·BMC Medical Imaging·Lene LillemarkUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Sep 10, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Per Kristian EideGeir Ringstad
Feb 28, 2016·Journal of Magnetic Resonance Imaging : JMRI·Yuanxin ChenJohn A Ronald
Jul 23, 2016·Journal of Neuropathology and Experimental Neurology·John W PrineasPaul D Kirwan
Apr 30, 2017·Journal of Alzheimer's Disease : JAD·Michala KolarovaRakez Kayed
Feb 19, 2019·Journal of Alzheimer's Disease : JAD·Lasse Melvaer GiilJan Erik Nordrehaug
May 8, 2020·Fluids and Barriers of the CNS·Peter SolárMarek Joukal
Sep 23, 2020·International Journal of Molecular Sciences·Ana C DuarteCecília R A Santos
Aug 4, 2020·Journal of Alzheimer's Disease : JAD·André FurtadoTelma Quintela
Sep 29, 2020·Frontiers in Aging Neuroscience·Christiana BjorkliIoanna Sandvig
Jan 15, 2021·International Journal of Molecular Sciences·Alan Zanardi, Massimo Alessio
Feb 29, 2020·Neurobiology of Aging·Ehsan TadayonUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jan 24, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Michelle L JamesFrederick T Chin

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Methods Mentioned

BETA
protein folding

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