PMID: 3213226Jan 1, 1988Paper

Pathological and clinical features of malignant thyroid tumors: classification, immunohistology, prognostic criteria

Veröffentlichungen aus der Pathologie
S Schröder

Abstract

In a retrospective analysis of 433 surgical specimens of malignant thyroid tumours, the prognostic efficiency of different morphological methods (conventional light microscopy, immunohistology, cytophotometric and flow cytometric DNA-estimations) was demonstrated. The clinical behaviour of the different forms of thyroid malignancy was predominantly determined by the histological type of neoplasia. High global values of significance were obtained when comparing the prognoses of follicular, papillary, medullary and anaplastic thyroid carcinomas as classified by the WHO. Their respective estimated survival curves are shown in Figure 37. As compared with the remaining thyroid carcinomas, papillary neoplasm altogether showed the significantly best long-term prognosis (p less than 0.001). Almost identical survival rates were recorded for patients with follicular and medullary carcinomas, which lay intermediate between the more favourable papillary and the in all cases fatal anaplastic tumours. Differences between these groups each time proved to be statistically significant (p less than 0.001). In addition, large differences also existed regarding the mode of tumour propagation for these carcinomas: papillary tumours usually showed l...Continue Reading

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