PMID: 9177799Jan 1, 1997Paper

Pathological and hemodynamic study in a new model of femoral head necrosis following traumatic dislocation

Archives of Orthopaedic and Trauma Surgery
M NishinoK Tomita

Abstract

The blood of the femoral head is thought to be supplied by vessels originating from the medial and lateral circumflex femoral arteries and via the marrow cavity of the neck. Therefore, it is difficult to induce osteonecrosis of the femoral head when the marrow cavity of the neck is preserved. In the present study, we established a new model of femoral head necrosis by dislocating the hip joint and ligating the medial and lateral circumflex femoral arteries and veins. Measurement of femoral head blood flow revealed that a marked decrease to 14.7% of the control value was achieved by both hip dislocation and ligation of blood vessels. Pathologic examination showed no necrosis with either dislocation or ligation alone, whereas at 2 and 4 weeks 80% of the animals subjected to both procedures showed widespread necrosis. These pathologic findings considered in the light of results of the blood flow measurements suggest that a decrease in femoral head blood flow below 20% of the control value is needed to cause osteonecrosis. In addition, magnetic resonance images (MRI) of the model were evaluated in the combined dislocation and ligation group at 4 weeks (n = 5). Changes on MRI were seen in 3 of 5 dogs. The necrotic changes of the fem...Continue Reading

References

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Citations

Jul 4, 2008·Der Orthopäde·P E BeauléM Leunig
Feb 23, 2011·Rheumatology International·Meng FanShibi Lu
Mar 29, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Michael G ConzemiusRobert A Robinson
Jul 4, 2012·Journal of Pediatric Orthopedics. Part B·Nguyen Ngoc Hung
Apr 2, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Zhen-Hong ZhuChang-Qing Zhang
Jul 25, 2013·The Journal of Surgical Research·Seung Hwan HongNam Hyuk Kim
Feb 11, 2015·Clinical Orthopaedics and Related Research·Nobuhiro KamiyaHarry K W Kim
Nov 20, 2010·Orthopaedics & Traumatology, Surgery & Research : OTSR·M EhlingerF Bonnomet
Feb 6, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Takashi TsujiHideki Yoshikawa
Oct 4, 2006·Clinical Orthopaedics and Related Research·Paul E BeauléPaul Shim
Jul 10, 2003·The Journal of Bone and Joint Surgery. American Volume·Claude T MoormanJoseph H Guettler
Jan 23, 2010·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·J F ZhangY Chen
Aug 16, 2000·Clinical Orthopaedics and Related Research·R D Salisbury, D M Eastwood
Feb 15, 2013·Experimental and Therapeutic Medicine·Qishun HuangZhenbing Chen
Dec 5, 2006·The Journal of Bone and Joint Surgery. American Volume·Paul E BeauléReinhold Ganz

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