Pathological and immunohistochemical study of experimental peste des petits ruminants virus infection in goats

Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health
P KumarS K Bandyopadhyay

Abstract

Peste des petits ruminants (PPR) is an emerging, economically important viral disease of goats and sheep in the Indian subcontinent. In the present investigation, 15 hill goats were experimentally infected with 2 ml of 10% splenic suspension of a virulent isolate of PPR virus (PPR/Izatnagar/94) that had caused heavy mortality (>75%) in goats during 1994 outbreaks in northern India. More than 86% (13 of 15) animals died between 9 and 13 days post inoculation at the height of temperature or when temperatures were declining. Necropsy findings included congestion of gastrointestinal tract (GIT), nasal sinuses, consolidation of antero-ventral lobes of lungs, engorged spleen, and occasionally oedematous lymph nodes. Histopathological examination of major organs of GIT revealed degeneration and necrosis of labial mucosa, severe mucosal and submucosal congestion, degeneration and necrosis of intestinal epithelium and lymphoid cell depletion from Peyer's patches along with presence of syncytia at times. Lungs showed broncho-interstitial changes and presence of intracytoplasmic and intranuclear eosinophilic inclusions in alveolar macrophages and syncytial cells. These changes in lungs were frequently complicated with serofibrinous pneumo...Continue Reading

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Citations

Jun 14, 2008·Tropical Animal Health and Production·Raveendra HegdeC Renukaprasad
Jun 18, 2008·Tropical Animal Health and Production·A Al-Naeem, E M E Abu-Elzein
Nov 23, 2011·Tropical Animal Health and Production·Vinayagamurthy BalamuruganKrishnamsetty Prabhudas
Feb 25, 2014·Veterinary Research·Jana BaronMichael D Baron
Oct 8, 2015·Veterinary Microbiology·S ParidaA C Banyard
Jan 18, 2012·Microbial Pathogenesis·Swapnil Pandurang JagtapPothukuchi Rama Vanamayya
Sep 29, 2005·Comparative Immunology, Microbiology and Infectious Diseases·K K RajakS K Bandyopadhyay
Apr 6, 2007·Reviews in Medical Virology·G J SipsN Wilczak
Jan 31, 2020·Acta Veterinaria Scandinavica·Edson KinimiGerald Misinzo
May 6, 2017·PloS One·Beatriz Sanz BernardoMichael D Baron

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