Pathological and immunohistochemical study of chickens with co-infection of Marek's disease virus and chicken anaemia virus

Avian Pathology : Journal of the W.V.P.A
Mohie HaridyKosuke Okada

Abstract

Chicken anaemia virus (CAV) is the most important confounding pathogen in Marek's disease virus (MDV) infection. The effect of CAV co-infection at 4 weeks of age after inoculation of virulent MDV (vMDV, KS strain) or very virulent MDV (vvMDV, Md/5 strain) in 1-day-old chicks was investigated by pathological and immunohistochemical studies. CAV increased the mortality rates induced by vMDV or vvMDV. The packed cell volume was reduced significantly in vMDV-CAV infection; however, no reduction or non-significant reduction was observed in vMDV infection. Bone marrow hypoplasia was related to CAV co-infection and none of the birds inoculated with vMDV or vvMDV had hypoplasia. Severe atrophy of the thymus and bursa of Fabricius was observed in the vvMDV-CAV and vvMDV groups. Complete regeneration of the thymus cortex and bursa of Fabricius in the vMDV group was noted and was in contrast to sequential lymphoid depletion after CAV inoculation in the vMDV-CAV group. The spleen was either regenerated, lymphoid depleted or had lymphoproliferative lesions. Lymphoid depletion in the spleen was not detected in the vMDV group; however, it was prominent in the vMDV-CAV and vvMDV-CAV groups during the first 2 weeks after CAV inoculation. CAV in...Continue Reading

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Citations

May 23, 2012·Emerging Infectious Diseases·Fabrizio MaggiMauro Pistello
Dec 3, 2014·Biologicals : Journal of the International Association of Biological Standardization·Ana Paula Muterle VarelaPaulo Michel Roehe
Jun 12, 2012·Research in Veterinary Science·M HaridyM Goryo
Oct 25, 2011·Veterinary Microbiology·Helton F dos SantosFrans A M Rijsewijk
Mar 25, 2017·Poultry Science·Sara López-OsorioJenny J Chaparro-Gutiérrez
Feb 2, 2012·The Journal of Veterinary Medical Science·Mohie HaridyMasanobu Goryo
Feb 21, 2018·The Journal of General Virology·Efstathios S GiotisPete Kaiser
Oct 20, 2018·Avian Diseases·I M Gimeno, K A Schat
Sep 15, 2017·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·O Yavuz, H Erer
Apr 23, 2020·Pathogens·Cynthia FengJose G Teodoro
Feb 27, 2013·Anatomia, histologia, embryologia·J P MadejA Wieliczko
Sep 29, 2020·Journal of Veterinary Research·Jie LiuZiqiang Cheng

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Software Mentioned

SPSS
SAS
Statistical Package for the Social Sciences

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