Pathological changes in broiler chickens fed ochratoxin A and inoculated with Escherichia coli

Avian Pathology : Journal of the W.V.P.A
Arvind KumarG E Rottinghaus

Abstract

A study was conducted to evaluate the effects of ochratoxin A (OA) on Escherichia coli-challenged broiler chickens. One hundred and eighty-four one-day-old broiler chicks were divided into two groups of 92 chicks each, with one group fed a control mash diet and the other fed a mash diet containing 2 parts/10(6) OA. On day 14, each group was further subdivided into two groups with one group inoculated with E. coli O78 (1 x 10(7) colony-forming units/0.5 ml) by the intraperitoneal route, whereas the other group was not inoculated with E. coli. Four birds from each group were sacrificed at 1, 2, 3, 5, 7, 10, 14 and 21 days post-inoculation to record pathological changes in the liver, kidneys, heart, lungs, bursa, spleen and thymus. E. coli infection induced perihepatitis and pericarditis in the liver and heart, respectively, in chickens infected with E. coli alone or in OA-fed birds from 1 day post-infection (DPI) onwards. At 1 DPI, a thin fibrin layer covered the liver and heart; however, at subsequent days, the layer became thicker. E. coli infection did not produce appreciable changes in the kidneys, bursa or thymus. However, there was congestion of the lungs along with mononuclear cell infiltration. Ochratoxin feeding induced ...Continue Reading

References

Apr 1, 1985·Poultry Science·L F KubenaN D Heidelbaugh
Jul 1, 1974·Poultry Science·W E HuffP B Hamilton
Aug 1, 1972·Die Naturwissenschaften·A CieglerL Leistner
Mar 13, 1965·Nature·K J van der MerweJ J Theron
Sep 1, 1982·Poultry Science·P B HamiltonR D Wyatt
Aug 1, 1994·Poultry Science·M H ElissaldeR B Harvey
Jul 31, 2003·Avian Diseases·A KumarG E Rottinghaus

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Citations

Jul 21, 2006·Avian Pathology : Journal of the W.V.P.A·M A ElaroussiM H Hatab
Jul 1, 2010·Toxins·Gianni BattaconeGiuseppe Pulina
Nov 11, 2011·Journal of Immunotoxicology·Zahoor Ul HassanMnaza Noreen
Feb 1, 2011·Journal of Immunotoxicology· Zahoor-Ul-HassanMuhammad Kashif Saleemi
Mar 7, 2006·Journal of Veterinary Pharmacology and Therapeutics·L Al-Anati, E Petzinger
Dec 10, 2020·Toxins·Philippe Guerre

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