Pathological changes in the formation of Helicobacter pylori-induced gastric lesions in Mongolian gerbils

Digestive Diseases and Sciences
S TakahashiS Okabe

Abstract

We examined pathological changes in the formation of Helicobacter pylori-induced gastric lesions in Mongorian gerbils. H. pylori (NCTC11637) was orally administered once to the animals and was detected in the gastric mucosa of all gerbils given the bacteria. The number of viable H. pylori increased during the initial two weeks and thereafter reached a plateau level. The initial pathological changes were found at one week, ie, edema/congestion and a white viscous substance only in the antrum. At two weeks, superficial damage appeared in the antrum, although inflammatory cell infiltration had not occurred. Gastritis with lymphoid follicles was observed in the antrum and fundus from three weeks. At four weeks, mucosal lesions were detected as a few hemorrhagic spots in the fundus adjacent to the antrum. In the control animals, however, no pathological changes were observed even at four weeks. In the gastric mucosa infected with H. pylori, myeloperoxidase activity was negligible at two weeks, but was extremely elevated at four weeks. Similarly, neutrophil chemotactic activity was only slightly increased at two weeks, but was markedly elevated at four weeks. These results indicate that H. pylori infection induces initial pathologica...Continue Reading

Citations

Oct 26, 2001·The Journal of Biological Chemistry·D A KeireJ R Reeve
Oct 30, 2001·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Y KetoS Okabe
Feb 3, 2005·Journal of Gastroenterology and Hepatology·Geoffrey M MatthewsRoss N Butler
Sep 27, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·S TakahashiA Yamamoto
Feb 8, 2002·World Journal of Gastroenterology : WJG·Yong-Li YaoWan-Dai Zhang
Jun 6, 2002·Alimentary Pharmacology & Therapeutics·R M Genta
Sep 27, 2005·Digestive Diseases and Sciences·Kazushi SakuraiKatsuya Yamasaki
Aug 5, 2005·Biological & Pharmaceutical Bulletin·Susumu Okabe, Kikuko Amagase
Jun 11, 2003·Journal of Gastroenterology and Hepatology·Hidekazu SuzukiHiromasa Ishii
Jan 7, 2005·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Susumu Okabe
Jun 23, 1999·FEMS Immunology and Medical Microbiology·J G Nedrud
Apr 5, 2000·Baillière's Best Practice & Research. Clinical Gastroenterology·A Lee
Jun 6, 2003·Free Radical Biology & Medicine·Masaharu MiyazawaHiromasa Ishii
Feb 24, 2001·Gastroenterology Clinics of North America·H Cohen

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