Oct 23, 2018

Pathological Changes of Tau Related to Alzheimer's Disease

ACS Chemical Neuroscience
Dandan Chu, Fei Liu


Alzheimer's disease (AD), the most common form of dementia, is characterized by extracellular β-amyloid plaques and intracellular neurofibrillary tangles (NFTs), which are considered as major targets for AD therapies. However, no effective therapy is available to cure or prevent the progression of AD up until now. Accumulation of NFTs, which consist of abnormally hyperphosphorylated tau, is directly correlated with the degree of dementia in AD patients. Emerging evidence indicates that the prion-like seeding and spreading of tau pathology may be the key driver of AD. In the past decades, greater understanding of tau pathway reveals new targets for the development of specific therapies. Here, we review the recent research progress in the mechanism underlying tau pathology in AD and briefly introduce tau-based therapeutics.

  • References
  • Citations1


  • We're still populating references for this paper, please check back later.
  • References
  • Citations1


Mentioned in this Paper

Biochemical Pathway
Neurofibrillary Degeneration (Morphologic Abnormality)
Plaque, Amyloid
Alzheimer's Disease
Diffuse Neurofibrillary Tangles With Calcification
Senile Plaques

Related Feeds

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a chronic neurodegenerative disease. This feed focuses on the underlying role of Tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's.

Related Papers

Cellular and Molecular Neurobiology
Fong Ping ChongSoi Moi Chye
Progress in Molecular Biology and Translational Science
Steven P BraithwaiteAngus C Nairn
© 2020 Meta ULC. All rights reserved