Pathological complete response after neoadjuvant/induction treatment: where is its place in the lung cancer staging system?†

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Hüseyin MelekCengiz Gebitekin

Abstract

Prognosis for patients with non-small-cell lung cancer (NSCLC) who, after neoadjuvant/induction and surgery, have a pathological complete response (pCR) is expected to be improved. However, the place of the pCR patients in the context of the tumour, lymph node and metastasis (TNM) staging system is still not defined. The aim of this study is to investigate the long-term survival of NSCLC patients with pCR and to find their appropriate staging category within the TNM staging system. We retrospectively reviewed the prospectively recorded data of 1076 patients undergoing surgery (segmentectomy or more) for NSCLC between 1996 and 2016. Patients were divided into 2 groups. Group 1: clinical early-stage patients who underwent direct surgical resection (n = 660); group 2: patients who received neoadjuvant/induction treatment before surgical resection for locally advanced NSCLC (n = 416). Morbidity, mortality, survival rates and prognostic factors were analysed and compared. Postoperative histopathological evaluation revealed pCR in 72 (17%) patients in group 2. Overall 5-year survival was 58.7% (group 1 = 62.3%, group 2 = 52.8%, P = 0.001). Of note, 5-year survival was 72.2% for pCRs. In addition, 5-year survival for stage 1a disease ...Continue Reading

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Citations

Feb 28, 2020·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Filippo LococoStefano Margaritora
Feb 28, 2020·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Huseyin MelekCengiz Gebitekin
Jan 16, 2021·General Thoracic and Cardiovascular Surgery·Özgür İşgörücü, Necati Citak
Mar 11, 2021·Cancer Communications·Jin KangWen-Zhao Zhong
Jun 10, 2021·Türk göğüs kalp damar cerrahisi dergisi·Mustafa Vedat DoğruMuzaffer Metin
Jun 12, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Dipesh UpretyAlex A Adjei
Mar 31, 2021·The Annals of Thoracic Surgery·Tianxiang ChenQingquan Luo
Nov 16, 2021·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Zuo LiuZhenfa Zhang

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