Pathological complete response induced by first-line chemotherapy with single agent docetaxel in a patient with advanced non small cell lung cancer.

World Journal of Surgical Oncology
Ferdinando RiccardiGiacomo Carteni'

Abstract

Defining the optimal treatment for patients with inoperable non small cell lung cancer (NSCLC), presenting with metastatic mediastinal lymph nodes, is challenging. Nevertheless, preoperative chemotherapy or radiotherapy might offer a chance for these patients for radical surgical resection and, possibly, complete recovery. A 62-year old man with IIIA-N2 inoperable NSCLC was treated with first-line single agent docetaxel. A platinum-based treatment, though considered more active, was ruled out because of renal impairment. The patient tolerated the treatment very well and, although his initial response was not impressive, after 14 cycles he obtained a complete clinical response, which was confirmed pathologically after he underwent surgical lobectomy. In non-operable NSCLC patients not eligible for a platinum-based treatment, single-agent docetaxel can provide complete pathologic responses. Failure to obtain a response after the first few cycles should not automatically discourage to continue treatment.

References

Jan 5, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alain DepierreUNKNOWN French Thoracic Cooperative Group
Nov 19, 2002·Clinical Breast Cancer·Steven D HeysUNKNOWN Aberdeen Breast Group
Dec 19, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K V MattsonK Krofta
Jul 29, 2004·JAMA : the Journal of the American Medical Association·Catherine DelbaldoJean-Pierre Pignon
Dec 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rogerio C LilenbaumMark R Green
Apr 26, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Wilfried EberhardtMartin Stuschke

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Citations

Aug 20, 2011·International Journal of Clinical Oncology·Takayuki TakimotoKinya Abe

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Methods Mentioned

BETA
surgical resection
biopsy

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