Pathological criteria and practical issues in papillary lesions of the breast - a review

Histopathology
Yun-Bi Ni, Gary M Tse

Abstract

Papillary lesions of the breast include a broad spectrum of lesions, ranging from benign papilloma, papilloma with atypical ductal hyperplasia (ADH) or ductal carcinoma in situ (DCIS) to papillary carcinoma. The accurate diagnosis of mammary papillary lesions is a challenge for pathologists, owing to the overlapping features among these lesions. In this review, some of the diagnostic criteria of papillary lesions are discussed, with special emphasis on some key morphological features, namely fibrovascular cores, epithelial proliferation in a solid pattern, intraductal papilloma complicated by ADH or DCIS, and invasion and its mimics. The roles of immunohistochemistry, and the interpretation of myoepithelial cell markers, hormone receptors, and high molecular weight cytokeratin, are addressed. Finally, novel biomarkers and genetic aberrations in papillary lesions are summarized.

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Citations

Jul 21, 2016·The American Journal of Surgical Pathology·Benjamin Yongcheng TanPuay Hoon Tan
Aug 5, 2017·The Journal of Pathology. Clinical Research·Matthias ChristgenHans Kreipe
Jan 7, 2021·International Journal of Surgical Pathology·Nah Ihm KimJi Shin Lee
Feb 10, 2021·Cancer Cytopathology·Shirley Kristina JamidiGary M Tse
Sep 14, 2020·Annals of Diagnostic Pathology·Alexandre A Vdovenko
Jul 23, 2021·Virchows Archiv : an International Journal of Pathology·Stuart J SchnittThomas Decker
Nov 5, 2021·Virchows Archiv : an International Journal of Pathology·Janina KulkaSigurd F Lax

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