Pathological diagnosis of Alzheimer-type dementia for old-old and oldest-old patients

Pathology International
T Mizutani

Abstract

The pathological diagnosis of Alzheimer-type dementia (ATD) is reviewed. The problems with the quantitative diagnosis are three-fold: the number of the senile plaques (SP) is not always related to the presence or the absence of dementia; recent research indicates that the SP and the neurofibrillary tangles (NFT) could represent a different level in the pathogenesis of ATD, and finally it has not been seriously discussed whether ATD is the final stage of physiological aging or if ATD is a definitive disease. For these reasons, new diagnostic criteria are proposed in order to differentiate ATD from physiological aging. The new criteria are suitable even in the old-old and oldest-old patients. It is stressed that ATD is heterogeneous in the pathogenetic aspect, consisting of Alzheimer's disease with onset before the age of 70 years (the neocortical type of ATD) and senile dementia of the Alzheimer type (the limbic type of ATD) with the onset after the age of 70. Even in cases with the latter type, there are several atypical ATD and non-ATD forms. "Primary senile dementia' is proposed as a comprehensive term to include various types of senile dementia of unknown etiology.

References

Mar 1, 1979·Annals of Neurology·K WisniewskiH M Wisniewski
Oct 1, 1976·The Journal of Comparative Neurology·O Steward, S A Scoville
Apr 1, 1992·Journal of the Neurological Sciences·T Mizutani, H Shimada
Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Mar 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·D NearyA N Davison
Nov 1, 1989·Journal of Neuropathology and Experimental Neurology·H M WísniewskiW Silverman
Jan 1, 1989·Acta Neuropathologica·H BraakP Kalus
Nov 1, 1985·Archives of Neurology·Z S Khachaturian
May 1, 1987·Journal of Neuropathology and Experimental Neurology·R D TerryR Katzman
Jul 1, 1988·Annals of Neurology·C L JoachimD J Selkoe
Nov 28, 1985·The New England Journal of Medicine·J H FoxS Savoy
Jan 1, 1973·The Psychiatric Quarterly·E M Gruenberg
Nov 1, 1973·Archives of Neurology·J M CoblentzR Katzman
Sep 1, 1970·Journal of the Neurological Sciences·B E TomlinsonM Roth
Sep 1, 1968·Journal of the Neurological Sciences·B E TomlinsonM Roth
Feb 1, 1966·The British Journal of Psychiatry : the Journal of Mental Science·W T SmithM Sim
Nov 9, 1995·The New England Journal of Medicine·T PolvikoskiK Kontula
Sep 1, 1993·The Japanese Journal of Psychiatry and Neurology·T AsadaM Atobe
Aug 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·M B SchapiroJ V Haxby
Mar 1, 1963·The Journal of Physiology·D H HUBEL, T N WIESEL

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Citations

Jan 6, 2000·Progress in Neurobiology·K OjikaN Matsukawa
Apr 11, 1997·Neuroscience Letters·Y NakamuraM Takeda
Mar 18, 2015·Acta Neuropathologica·Kurt A JellingerThomas Wisniewski
Apr 14, 1999·Psychiatry and Clinical Neurosciences·K KosakaH Arai
May 10, 2005·Journal of the American Geriatrics Society·Annette ErlangsenBernard Jeune
Apr 22, 1999·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Y TsuguS Mitake
Apr 18, 1998·Brain Pathology·K A Jellinger, C Bancher

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