Pathological findings and prognostic factors in recurrent glioblastomas

Brain Tumor Pathology
Yoshiko OkitaSoichiro Shibui

Abstract

Glioblastomas, which are the most common primary intracranial tumor, are associated with the poorest survival time, which is typically 1-2 years. Age at initial diagnosis, Karnofsky performance score, and O(6)-methylguanine DNA-methyltransferase (MGMT) promoter methylation status are the most well-documented predictors of survival in patients with newly diagnosed glioblastoma. Few studies have examined prognostic factors in patients with recurrent glioblastomas. At relapse, the pathological features of glioblastomas are affected by tumor regrowth and the influence of chemoradiotherapy during the initial treatment. Morphological transformations at recurrence include quantitative changes in tumor cells, such as the presence of giant cells and gemistocytic cell formation, radiation necrosis, and vascular structural changes. Therefore, we should carefully examine pathological findings at recurrence. In this report, we analyzed MGMT promoter status, the MIB-1 index, and the pathology of tumor samples at the first (primary tumor) and second (recurrent tumor) surgeries and clarified prognostic factors in patients with recurrent cases. In the multivariate analysis, we showed that MIB-1 indexes at the time of the second surgery (p = 0.0...Continue Reading

References

Dec 1, 1985·Neurologia Medico-chirurgica·M OgashiwaK Akai
Apr 1, 1987·Neurologia Medico-chirurgica·M OgashiwaK Akai
Sep 11, 1999·Neurologia Medico-chirurgica·K KunishioT Ohmoto
May 9, 2002·Journal of Neuro-oncology·Roland SchröderRalf-Ingo Ernestus
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Mar 11, 2005·The New England Journal of Medicine·Monika E HegiRoger Stupp
Oct 20, 2005·Journal of Neuro-oncology·Shaye I MoskowitzRichard A Prayson
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kathryn A CarsonEdward G Shaw
Nov 16, 2007·Journal of Neuro-oncology·Jonathon F ParkinsonKerrie L McDonald

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Citations

Jan 1, 2014·CNS Oncology·James S HaleJustin D Lathia
Sep 19, 2015·Clinical Oncology : a Journal of the Royal College of Radiologists·C GzellM Back
Aug 29, 2012·Neurological Research·Sung-Geun ParkSam-Suk Kang
Nov 1, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·A Dullea, L Marignol
Feb 17, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Wen-Jie ChenGang Chen
Oct 19, 2013·Oncology Letters·Pin GuoYongming Qiu
Sep 11, 2021·Scientific Reports·Rikke H DahlrotBjarne W Kristensen

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