Pathological Left Ventricular Hypertrophy and Stem Cells: Current Evidence and New Perspectives

Stem Cells International
Maria E MarketouPanos E Vardas

Abstract

Left ventricular hypertrophy (LVH) is a strong predictor of adverse cardiovascular outcomes. It is the result of complex mechanisms that include not only an increase in protein synthesis and cell size but also proliferating cardiac progenitor cells and the influx of bone marrow-derived cells developing into cardiomyocytes. Stem and progenitor cells are known to contribute to the renewal of adult mammalian cardiomyocytes in case of myocardial injury or pressure and volume overload. They are activated in LVH and play a regulatory role in myocardial repair. They have high proliferative potential and secrete numerous cytokines, growth factors, and microRNAs that play important roles in cell differentiation, cardiac remodeling, and neovascularization. They are mobilized in response to either mechanical or chemical stimuli, hormones, or pharmacologic agents. Another important source of progenitor cells is the epicardial layer. It appears that precursor cells migrate from the epicardium to the myocardium in order to interact with myocardial cells. In addition, migratory cells participate in the formation of almost all cardiac structures in myocardial hypertrophy. Although the pathophysiological mechanisms are still obscure and further...Continue Reading

References

Apr 1, 1996·The Journal of Experimental Medicine·M A GoodellR C Mulligan
Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·G A DabiriJ W Sanger
Jan 29, 1999·Physiological Reviews·B Swynghedauw
Jan 5, 2002·The New England Journal of Medicine·Federico QuainiPiero Anversa
Apr 6, 2002·Circulation Research·Michael A LaflammeCharles E Murry
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Xue ZhaoQingping Feng
Aug 21, 2003·Proceedings of the National Academy of Sciences of the United States of America·Konrad UrbanekPiero Anversa
Sep 25, 2003·Cell·Antonio P BeltramiPiero Anversa
Oct 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hidemasa OhMichael D Schneider
Dec 31, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Jin HurYoung-Bae Park
Feb 1, 2005·The Journal of Pathology·Roberta FiaccaventoPaolo Di Nardo
Feb 28, 2006·Nature Clinical Practice. Cardiovascular Medicine·Daniele TorellaBernardo Nadal-Ginard
Jun 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Konrad UrbanekAnnarosa Leri
Sep 23, 2006·The New England Journal of Medicine·Volker SchächingerUNKNOWN REPAIR-AMI Investigators
Mar 3, 2007·The Journal of Clinical Investigation·Bradford C BerkStephanie Lehoux
May 30, 2007·Archives of Internal Medicine·Ahmed Abdel-LatifBuddhadeb Dawn
Nov 17, 2007·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Joanna E KontarakiPanos E Vardas
Mar 29, 2008·Cell Stem Cell·Kathryn N IveyDeepak Srivastava
May 16, 2008·Nature·Chen-Leng CaiSylvia M Evans
Aug 30, 2008·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Volker AdamsStefan Möhlenkamp
Oct 3, 2008·The Journal of Clinical Investigation·Risto KerkelaGordon S Huggins
Mar 17, 2009·Stem Cells and Development·Kitchener D WilsonJoseph C Wu
Apr 4, 2009·Science·Olaf BergmannJonas Frisén
Jan 19, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Joost P G SluijterMarie-José Goumans
May 22, 2010·Journal of Molecular and Cellular Cardiology·Sandra B HaudekMark L Entman
Aug 24, 2010·Journal of Molecular and Cellular Cardiology·Maria MirotsouVictor J Dzau
Aug 25, 2010·Circulation. Cardiovascular Genetics·Kitchener D WilsonJoseph C Wu
Oct 30, 2010·Journal of Cellular and Molecular Medicine·Cinzia FortiniCarlo Alberto Beltrami

❮ Previous
Next ❯

Citations

Aug 31, 2017·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Andrei TodicaSebastian Lehner
Dec 14, 2019·Stem Cell Reviews and Reports·Maria Teresa ValentiMonica Mottes
Mar 16, 2017·Journal of Cellular and Molecular Medicine·Xiao-Hui GuanHong-Bo Xin

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Cardiac Regeneration

Cardiac regeneration enables the repair of irreversibly damaged heart tissue using cutting-edge science, including stem cell and cell-free therapy. Discover the latest research on cardiac regeneration here.

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.