Pathological Lesions and Inducible Nitric Oxide Synthase Expressions in the Liver of Mice Experimentally Infected with Clonorchis sinensis

The Korean Journal of Parasitology
Qing-Li YangXiao-Nong Zhou

Abstract

The nitric oxide (NO) formation and intrinsic nitrosation may be involved in the possible mechanisms of liver fluke-associated carcinogenesis. We still do not know much about the responses of inducible NO synthase (iNOS) induced by Clonorchis sinensis infection. This study was conducted to explore the pathological lesions and iNOS expressions in the liver of mice with different infection intensity levels of C. sinensis. Extensive periductal inflammatory cell infiltration, bile duct hyperplasia, and fibrosis were commonly observed during the infection. The different pathological responses in liver tissues strongly correlated with the infection intensity of C. sinensis. Massive acute spotty necrosis occurred in the liver parenchyma after a severe infection. The iNOS activity in liver tissues increased, and iNOS-expressing cells with morphological differences were observed after a moderate or severe infection. The iNOS-expressing cells in liver tissues had multiple origins.

References

Sep 2, 1998·Digestive Diseases and Sciences·Y ShiratoriM Omata
Aug 3, 2002·The British Journal of Surgery·P Watanapa, W B Watanapa
Aug 5, 2003·Parasitology Research·Yang Kyu ChoiDae Yong Kim
Oct 17, 2003·Current Drug Targets. Inflammation and Allergy·Philipp LirkJosef Rieder
Jun 5, 2004·Regulatory Peptides·Vassilis ValatasElias A Kouroumalis
Jul 20, 2004·Clinical Microbiology Reviews·Byung Ihn ChoiKyoung Ho Lee
Dec 29, 2004·The Lancet Infectious Diseases·Zhao-Rong LunYue-Yi Fang
May 26, 2005·Seminars in Cancer Biology·Matthias LechnerJosef Rieder
Sep 13, 2005·Journal of Helminthology·H-J Rim
Jul 1, 2006·The Korean Journal of Parasitology·Woon-Mok SohnSung-Tae Hong
Nov 16, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Manfred BilzerAlexander L Gerbes
Jul 12, 2011·Parasitology International·Sung-Tae Hong, Yueyi Fang
Sep 6, 2011·European Heart Journal·Ulrich Förstermann, William C Sessa
Jul 24, 2012·Immunology Letters·Qiao YangZhi Chen
Nov 30, 2012·Future Medicinal Chemistry·Naveena B Janakiram, Chinthalapally V Rao
Jun 4, 2013·Journal of Hepatology·Veronika Lukacs-Kornek, Detlef Schuppan
Jun 25, 2013·Cancer Biology & Therapy·Shu Wen WenChristopher Christophi
Jan 1, 2012·Infectious Diseases of Poverty·Men-Bao QianXiao-Nong Zhou
Jan 11, 2014·Journal of Hepato-biliary-pancreatic Sciences·Paiboon SithithawornChawalit Pairojkul
Jun 21, 2014·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Hasan ÖzenOnur Atakişi

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