Pathological process has a crucial role in sentinel node biopsy for vulvar cancer

Gynecologic Oncology
Peter SykesBryony Simcock

Abstract

To report the interim findings of an audit of the outcomes of sentinel node (SN) biopsy performed as a replacement for groin node dissection in women with early stage vulvar cancer in routine clinical practice in Australia and New Zealand. A prospective multi-center study in 8 participating centers. Eligible patients had squamous cell carcinomas clinically restricted to the vulva <4 cm in diameter. SN procedures and pathological assessment were to be performed in accordance with the methods published by the GROINSS-V collaboration [1]. 130 women with apparent early stage vulvar cancer were enrolled. Seventeen women subsequently did not meet the eligibility criteria and were excluded. SNs were identified in 111/113 of the remaining women. Twenty-two women had positive nodes. Sixteen of these women had at least 12 months follow up and 7 (44%) had recurrent disease. Eighty-nine women had only negative nodes. Seventy-four of these women had at least 12 months follow up and 6 (8%) had recurrent disease (including 2 [2.7%] with recurrence in the groin). On subsequent review of the two women with negative SNs who had groin recurrences, it was found that the recommended pathology protocol had not been followed. In both cases, SN metast...Continue Reading

Citations

Jan 4, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Angela CollarinoMarco Maccauro
Jan 3, 2021·International Journal of Clinical Oncology·Haifeng GuHua Tu
Dec 18, 2019·Seminars in Nuclear Medicine·Valeria M MoncayoJohn N Aarsvold
Feb 11, 2020·Bulletin du cancer·Nadjla Alsadoun, Mojgan Devouassoux-Shisheboran

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