Pathological risk factors and predictive endoscopic factors for lymph node metastasis of T1 colorectal cancer: a single-center study of 846 lesions

Journal of Gastroenterology
Chihiro YasueJunko Fujisaki

Abstract

Determining the depth of invasion of early stage colorectal cancer has been emphasized as a means of improving endoscopic diagnostic accuracy. Recent studies have focused on other pathological risk factors for lymph node metastasis (LNM). We investigated the significance of depth of invasion and predictive properties of other endoscopic findings. We retrospectively investigated 846 patients with submucosal invasive (T1) colorectal cancer who received an accurate pathological diagnosis and were treated between January 2005 and December 2016. Pathological risk factors associated with LNM were reviewed. We divided patients into groups: low-risk T1 colorectal cancer (LRC; no risk factors) and high-risk T1 colorectal cancer (HRC; exhibiting lymphovascular invasion, tumor budding grade of 2/3, and/or poor differentiation) and studied predictive endoscopic factors for HRC. Significant risk factors for LNM in multivariate analysis were lymphovascular invasion [odds ratio (OR) 8.09; 95% confidence interval (CI) 3.84-17.1], tumor budding (OR 1.89; 95% CI 1.09-3.29), and histological differentiation (OR 2.09; 95% CI 1.12-3.89). The LNM-positive rate with only deep submucosal invasion was 1.6%. Significant predictive factors for HRC in mul...Continue Reading

References

Jul 1, 1996·Gastrointestinal Endoscopy·S KudoH Watanabe
Feb 20, 2002·Diseases of the Colon and Rectum·Riccardo NascimbeniDirk R Larson
Sep 10, 2008·The American Journal of Surgical Pathology·Elizabeth I HarrisMary K Washington
Mar 23, 2010·Diseases of the Colon and Rectum·Seok-Byung LimJin Cheon Kim
May 18, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Yoko TateishiSatoshi Umemura
Nov 13, 2010·World Journal of Gastroenterology : WJG·Hao WangFu-Ao Cao
Dec 15, 2010·Journal of Gastroenterology·Hirotoshi KobayashiKenichi Sugihara
Feb 16, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Alexander MeiningWolfgang Schmitt
Dec 7, 2011·Journal of Gastroenterology and Hepatology·Koichi NakadoiKazuaki Chayama
Jan 20, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Sean C GlasgowAnn C Lowry
Mar 14, 2012·Journal of the Korean Society of Coloproctology·Min Ae KeumJin Cheon Kim
Nov 2, 2012·International Journal of Clinical Oncology·Hiroo WadaYohei Miyagi
Dec 13, 2012·Gastroenterology·Hiroaki IkematsuYutaka Saito
Jan 22, 2013·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C BeatonA G Radcliffe
May 3, 2013·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Shiro OkaKazuaki Chayama
Jul 22, 2014·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Shinji TanakaKazuaki Chayama
Jun 17, 2015·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Yusuke SaitohMikihiro Fujiya
Dec 8, 2015·Journal of Gastroenterology and Hepatology·Hideyuki MiyachiShigeharu Hamatani
Jun 9, 2016·Langenbeck's Archives of Surgery·Erman AytacHermann Kessler
Mar 30, 2017·International Journal of Clinical Oncology·Toshiaki WatanabeUNKNOWN Japanese Society for Cancer of the Colon and Rectum
Mar 31, 2017·Oncology Letters·Katsuro IchimasaFumio Ishida

❮ Previous
Next ❯

Citations

Sep 12, 2019·Archives of Pathology & Laboratory Medicine·Catherine E Hagen, Ayesha Farooq
Oct 1, 2020·World Journal of Gastrointestinal Endoscopy·Yoshika AkimotoTetsuo Nemoto
Sep 10, 2020·Endoscopy International Open·Kim GijsbersUNKNOWN (on behalf of the Dutch T1 CRC Working Group)
Jun 18, 2020·International Journal of Colorectal Disease·Kenichi MochizukiHideyuki Miyachi
Oct 13, 2020·Endoscopy International Open·Mathieu Pioche, Yutaka Saito
Aug 15, 2020·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Federica RocchettiUmberto Romeo
Apr 27, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Muhammad A JavedShakil Ahmed
Jun 18, 2021·Frontiers in Oncology·Yansong XuWeizhong Tang
Dec 24, 2021·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Katsuro IchimasaMasashi Misawa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.