Pathological role of CD44 on NKT cells in carbon tetrachloride-mediated liver injury

Hepatology Research : the Official Journal of the Japan Society of Hepatology
Kiminori KimuraKazuhiro Kakimi

Abstract

CD44 has a variety of functions in immune regulation and signal transduction. Although CD44 is involved in the induction of several inflammatory diseases, it remains unknown whether CD44-targeting therapies are useful for liver diseases. Here, we examined whether CD44 blockade is effective in a chemical-induced liver injury model. We injected CD44 knock out (KO) or wild type mice with carbon tetrachloride (CCl(4)) and examined the difference of liver injury by immunological or histological analysis. Although CD44KO mice exhibited suppressed liver injury at 6 h after CCl(4) injection with decreased inflammatory cell numbers and cytokine production, these mice showed severe liver injury at 24 h. We found that NKT cells played an important role in liver injury with increased infiltration of theliver after migration, which was independent of the CD44 pathway. In CD44NKT double-KO mice, liver injury was suppressed with reduced cytokine production and macrophage infiltration compared with CD44KO mice. Furthermore, MIP-2 derived from NKT cells or tumor necrosis factor alpha from macrophages contributed to exacerbation of the liver injury, since neutralization of MIP-2 provided significant protection against liver injury in CD44KO mice...Continue Reading

References

May 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M PetersJ H Hoofnagle
Sep 1, 1990·The Journal of Experimental Medicine·P Tekamp-OlsonA Cerami
Apr 1, 1987·Liver·E N Wardle
May 20, 1998·Proceedings of the National Academy of Sciences of the United States of America·T KawanoM Taniguchi
Jan 25, 2000·The Journal of Biological Chemistry·S L Friedman
Mar 11, 2000·The Journal of Clinical Investigation·M H SiegelmanP Estess
Oct 4, 2000·The Journal of Experimental Medicine·K KakimiF V Chisari
Feb 13, 2001·European Journal of Immunology·G MatsumotoJ M Penninger
Mar 13, 2001·Annual Review of Immunology·L G Guidotti, F V Chisari
Apr 6, 2002·Science·Priit TederPaul W Noble
Oct 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kiminori KimuraFrancis V Chisari
Dec 6, 2002·The American Journal of Pathology·Qin WangClaire M Doerschuk
Dec 19, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hartmut Jaeschke
Jan 4, 2003·Nature Reviews. Immunology·Ian Nicholas Crispe
Jan 25, 2003·Annual Review of Immunology·Masaru TaniguchiHiroshi Wakao
May 17, 2003·The Journal of Clinical Investigation·Shigeki KatohShigeru Matsukura
Oct 8, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Goichi MatsumotoJosef M Penninger
Oct 16, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kiminori KimuraHisataka Moriwaki
Dec 21, 2005·The Journal of Experimental Medicine·Ken-Ichiro Seino, Masaru Taniguchi
Feb 4, 2006·Blood·Eric VachonGregory P Downey
Mar 2, 2006·The American Journal of Pathology·Kiminori KimuraFrancis V Chisari
Jul 21, 2007·The Journal of Clinical Investigation·Ramesh C HalderVipin Kumar
Jan 15, 2008·Journal of Hepatology·Woo-Yong Lee, Paul Kubes
Apr 9, 2008·Journal of Hepatology·Kiminori KimuraHisataka Moriwaki

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Citations

Jun 18, 2009·Seminars in Immunopathology·Fabio MarraAngela Provenzano
Nov 22, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Damião C M dos SantosMarcelo Alves Pinto
Aug 4, 2010·Expert Review of Gastroenterology & Hepatology·Massimo Pinzani, Jose Macias-Barragan

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