Pathological scenario with the mannose-binding lectin in patients with IgA nephropathy.

Journal of Biomedicine & Biotechnology
Isao OhsawaYasuhiko Tomino

Abstract

A deeper understanding of the mechanism of complement activation may help to elucidate the pathogenesis of IgA nephropathy (IgAN). Traditionally, the activation of an alternative pathway (AP) has been recognized as an enhancer mechanism of glomerular damage. This paper documents contemporary information concerning the possible pathological mechanisms of the lectin pathway (LP) in the circulation and in the glomerulus. The circulating initiator of LP activation is not fully understood. However, ligands for mannose-binding lectin (MBL) which are among the starter molecules of the LP are aberrant glycosylated molecules-containing immune complex. Recent reports have focused on N-glycans on secretory IgA as a candidate ligand. Mesangial deposits of MBL are seen in 25% of patients with IgAN. Mesangial deposits of MBL and C4 and/or C4 breakdown products are implicated as markers for disease progression of IgAN. On the other hand, patients with MBL deficiency tend to show better clinical presentation and lower levels of urinary protein and serum creatinine than MBL-sufficient patients. It is now recognized that involvement of AP and LP constitutes an additional mechanism for explaining the progression of IgAN.

References

Jun 1, 1992·Kidney International·L A van Es
Nov 1, 1988·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R J Wyatt, B A Julian
Jan 1, 1984·Contributions to Nephrology·A VangelistaV Bonomini
Nov 5, 1981·The New England Journal of Medicine·Y TominoH Sakai
Jun 1, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M Haas
Nov 25, 1997·Accident; Analysis and Prevention·V ShankarF Mannering
Aug 27, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M EndoT Fujita
May 18, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·K LhottaP König
Mar 29, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·D PirulliA Amoroso
Aug 18, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A RoosM R Daha
Oct 3, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·I OhsawaT Fujita
Oct 31, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S HisanoS Takebayashi
Sep 6, 2002·The New England Journal of Medicine·James V Donadio, Joseph P Grande
Mar 15, 2003·The Journal of Biological Chemistry·Louise RoylePauline M Rudd
Apr 17, 2004·Kidney International·Rosanna Coppo, Alessandro Amore
Mar 9, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Shinji HagiwaraYasuhiko Tomino
Sep 1, 2005·Journal of Clinical Immunology·M M DeanD P Eisen
Jan 6, 2006·Genes and Immunity·P GarredH O Madsen
May 12, 2006·Journal of the American Society of Nephrology : JASN·Anja RoosMohamed R Daha
Mar 28, 2007·Journal of Clinical Laboratory Analysis·Kisara OndaYasuhiko Tomino
Jun 2, 2007·Pathology International·Satoshi HisanoHiroshi Iwasaki
Jun 5, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Beatrijs D OortwijnCees van Kooten
Oct 10, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mario EspinosaPedro Aljama
May 13, 2010·Clinical and Experimental Nephrology·Gaku KusabaYasuhiko Tomino
Feb 9, 2011·Current Opinion in Nephrology and Hypertension·Richard J Glassock
Sep 29, 2011·Journal of the American Society of Nephrology : JASN·Hitoshi SuzukiBruce A Julian

❮ Previous
Next ❯

Citations

Dec 12, 2013·Journal of Clinical Immunology·Lu LiuGuolan Xing
Jul 15, 2016·Nephrology·Rafaela Cabral Gonçalves FabianoAna Cristina Simões E Silva
Feb 16, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rosanna Coppo
Jul 13, 2017·Journal of the American Society of Nephrology : JASN·Wei-Yi GuoHong Zhang
Jun 29, 2016·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Rafaela Cabral Gonçalves FabianoAna Cristina Simões E Silva
Apr 18, 2020·Virchows Archiv : an International Journal of Pathology·Hiroe ItamiChiho Ohbayashi
Apr 11, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rosanna CoppoUNKNOWN VALIGA Study Group of the ERA-EDTA Immunonephrology Working Group

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
glycosylations
glycosylation

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Related Papers

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
M EndoT Fujita
Seminars in Nephrology
Beatrijs D OortwijnCees van Kooten
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Jan NovakRobert J Wyatt
© 2021 Meta ULC. All rights reserved