Pathological severity determines the renal recovery for anti-myeloperoxidase antibody-associated vasculitis requiring dialysis at disease onset: a retrospective study

BMC Nephrology
Peng-Cheng XuTie-Kun Yan

Abstract

Many patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) need dialysis at disease onset due to severe kidney injury. Determining whether they can become dialysis independent is an important clinical assessment. Forty kidney biopsy-proved myeloperoxidase (MPO)-ANCA associated AAV patients who required dialysis at disease onset were enrolled. Relationships between laboratory and pathological characteristics and prognoses were analyzed. Twenty-five patients obtained dialysis independence within 3 months, while the other 15 patients remained dialysis dependent. No sclerotic class was identified among the 40 patients. Only two biopsies exhibited focal class diagnoses and both these patients recovered their renal function. The renal recovery rate of the 20 patients with mixed class was significantly lower than that of the 18 patients with crescentic class (40.0% vs. 83.3%, p = 0.006). Receiver operating characteristics (ROC) curves showed fibrous crescent+global glomerulosclerosis greater than 32.6% was a strong predictor of dialysis dependence with a sensitivity of 93.3% and specificity of 88.0%. When the percentage of fibrous crescent+global glomerulosclerosis exceeded 47.9%, dialysis independence ...Continue Reading

References

Apr 1, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Anthony D BoothUNKNOWN Pan-Thames Renal Research Group
Jun 22, 2007·Journal of the American Society of Nephrology : JASN·David R W JayneUNKNOWN European Vasculitis Study Group
Jun 11, 2010·Clinical and Experimental Nephrology·Chems GharbiHassane Izzedine
Jul 10, 2010·Journal of the American Society of Nephrology : JASN·Annelies E BerdenIngeborg M Bajema
Nov 29, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Dong-yuan ChangMing-hui Zhao
Aug 28, 2012·Autoimmunity Reviews·Renato A SinicoAntonella Radice
Oct 10, 2012·Arthritis and Rheumatism·J C JennetteR A Watts
Jan 26, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Wen TangDavid W Johnson
Jun 15, 2013·Journal of the American Society of Nephrology : JASN·Marc HilhorstUNKNOWN Limburg Renal Registry
Feb 27, 2014·QJM : Monthly Journal of the Association of Physicians·M RomeuN Jourde-Chiche
Apr 22, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Luis F QuintanaDavid Jayne
May 20, 2014·Rheumatology International·Godasi S R S N K NaiduManish Rathi
Jul 2, 2014·Nature Reviews. Rheumatology·Cees G M Kallenberg
Jul 14, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Anisha TannaCharles D Pusey
Mar 7, 2015·Scandinavian Journal of Rheumatology·P WillekeH Schotte
Nov 1, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Rune BjørneklettLeif Bostad
Feb 6, 2017·Clinical Journal of the American Society of Nephrology : CJASN·Yinghua ChenWeixin Hu

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Methods Mentioned

BETA
biopsy
biopsies
light microscopy

Software Mentioned

SPSS

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