Abstract
The aim of the present study was to obtain a full view of the changes of urinary complement activation products in the development of diabetic nephropathy and explore their possible significance in the disease process. A total of 62 patients at different stages of diabetic nephropathy, 20 diabetes patients without nephropathy and 20 healthy persons were enrolled. Urinary complement activation products, including C3a, C5a and C5b-9, were measured, and their associations with the progression of the disease were analyzed. The urinary complement activation products increased markedly since the proteinuria stage, and were parallel with the progression of diabetic nephropathy. More severe renal tubular damage was observed in patients with higher levels of urinary complement activation products. The urinary complement activation products levels correlated closely with renal tubulointerstitial injury score and relative tubular interstitial volume. Multivariate regression analysis showed that elevated urinary complement activation products were independent risk factors for tubular injury in diabetic nephropathy patients. Urinary complement activation might have a role in renal tubular interstitial injury in patients with diabetic nephro...Continue Reading
References
Dec 1, 1991·Kidney International·J L OgrodowskiW Kolb
May 21, 2003·American Journal of Veterinary Research·Christopher J DuttonAnn M Gronowski
Oct 21, 2003·American Journal of Nephrology·Krzysztof OkonMarek Kuzniewski
Feb 18, 2004·Internal Medicine·Masaomi Nangaku
Jan 23, 2009·Journal of the American Society of Nephrology : JASN·Ziyong TangNeil S Sheerin
Feb 20, 2010·Journal of the American Society of Nephrology : JASN·Thijs W Cohen TervaertUNKNOWN Renal Pathology Society
Nov 25, 2011·BMC Nephrology·Kisara OndaYasuhiko Tomino
Jul 17, 2012·Journal of the American Society of Nephrology : JASN·Qi PengWuding Zhou
Sep 4, 2012·Journal of Clinical Immunology·Rui MaMing-hui Zhao
Sep 28, 2012·Thrombosis and Haemostasis·Hongjie WangBerend Isermann
Apr 9, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel Ricklin, John D Lambris
Oct 12, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Shen-Ju GouMin Chen
Nov 12, 2013·The New England Journal of Medicine·Linda F FriedUNKNOWN VA NEPHRON-D Investigators
Nov 12, 2013·The New England Journal of Medicine·Dick de ZeeuwUNKNOWN BEACON Trial Investigators
May 3, 2014·Kidney International·Mark E MolitchCarl E Mogensen
Jun 25, 2014·Hypertension·Richard M BurwickBruce B Feinberg
Oct 25, 2014·International Journal of Nephrology and Renovascular Disease·Andy Kh Lim
Nov 26, 2014·PloS One·Ling LiFang Liu
Feb 11, 2015·American Journal of Nephrology·Katherine J KellyJesus H Dominguez
Apr 11, 2015·Endocrine Reviews·Pamela GhoshJose A Halperin
Mar 7, 2017·Nature Reviews. Nephrology·Allan Flyvbjerg
Apr 1, 2018·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jing-Min ZhengLi-Juan Li
May 8, 2018·Diabetes & Metabolism·X-Q LiM-H Zhao
Citations
Dec 18, 2019·Diabetes/metabolism Research and Reviews·Sicco A BusTessa Busch-Westbroek
Jan 17, 2020·Nature Reviews. Nephrology·Sydney C W Tang, Wai Han Yiu
Jul 3, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Thuan Huynh QuangThuan Nghiem Duc
Sep 26, 2020·Frontiers in Immunology·Shuang GaoMing-Hui Zhao
Jan 29, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shengfeng WanFengmin Shao
Feb 9, 2021·Frontiers in Medicine·Kelly BudgePaolo Cravedi
May 28, 2021·Journal of Endocrinological Investigation·L ZhaoN Tong
May 21, 2021·Analytical Cellular Pathology (Amsterdam)·Lanlan LiWeiping Lu
Nov 23, 2021·Antioxidants & Redox Signaling·Sih Min TanMelinda T Coughlan