Pathological significance of urinary complement activation in diabetic nephropathy: A full view from the development of the disease

Journal of Diabetes Investigation
Jing-Min ZhengLi-Juan Li

Abstract

The aim of the present study was to obtain a full view of the changes of urinary complement activation products in the development of diabetic nephropathy and explore their possible significance in the disease process. A total of 62 patients at different stages of diabetic nephropathy, 20 diabetes patients without nephropathy and 20 healthy persons were enrolled. Urinary complement activation products, including C3a, C5a and C5b-9, were measured, and their associations with the progression of the disease were analyzed. The urinary complement activation products increased markedly since the proteinuria stage, and were parallel with the progression of diabetic nephropathy. More severe renal tubular damage was observed in patients with higher levels of urinary complement activation products. The urinary complement activation products levels correlated closely with renal tubulointerstitial injury score and relative tubular interstitial volume. Multivariate regression analysis showed that elevated urinary complement activation products were independent risk factors for tubular injury in diabetic nephropathy patients. Urinary complement activation might have a role in renal tubular interstitial injury in patients with diabetic nephro...Continue Reading

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Citations

Dec 18, 2019·Diabetes/metabolism Research and Reviews·Sicco A BusTessa Busch-Westbroek
Jan 17, 2020·Nature Reviews. Nephrology·Sydney C W Tang, Wai Han Yiu
Sep 26, 2020·Frontiers in Immunology·Shuang GaoMing-Hui Zhao
Jan 29, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shengfeng WanFengmin Shao
Feb 9, 2021·Frontiers in Medicine·Kelly BudgePaolo Cravedi
May 21, 2021·Analytical Cellular Pathology (Amsterdam)·Lanlan LiWeiping Lu
Nov 23, 2021·Antioxidants & Redox Signaling·Sih Min TanMelinda T Coughlan

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Methods Mentioned

BETA
biopsy
urine collection
biopsies
electron microscopy

Software Mentioned

SPSS

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